Tsai T F, Cobb W B, Bolin R A, Gilman N J, Smith G C, Bailey R E, Poland J D, Doran J J, Emerson J K, Lampert K J
Am J Epidemiol. 1987 Sep;126(3):460-73. doi: 10.1093/oxfordjournals.aje.a114677.
An epidemic of St. Louis encephalitis in 1985 in Mesa County, Colorado, led to 17 cases, including one fatality. Risk was associated with advanced age and residence in Grand Junction, the county's principal city. A trend was observed toward higher risk in females. However, increased risk in females was not associated with higher infection rates (increased exposure). Capture enzyme immunoassays detected specific immunoglobulin M (IgM) and immunoglobulin A after infection. A serosurvey of Grand Junction residents disclosed an infection rate of 4.0%, indicating that 1,123 epidemic St. Louis encephalitis infections may have occurred in the city. Evidence of previous St. Louis encephalitis virus infection was found in 11.2% of survey respondents who had neutralizing antibody to the virus without specific IgM. The prevalence of St. Louis encephalitis virus antibody was similar to rates observed in serosurveys undertaken 30 years earlier, indicating that the level of endemic St. Louis encephalitis transmission in the city had not changed appreciably in that interval.
1985年，科罗拉多州梅萨县爆发圣路易斯脑炎疫情，导致17人感染，其中1人死亡。风险与高龄以及居住在该县主要城市大章克申有关。观察到女性的风险有升高趋势。然而，女性风险增加与感染率升高（暴露增加）无关。捕获酶免疫测定法可在感染后检测到特异性免疫球蛋白M（IgM）和免疫球蛋白A。对大章克申居民的血清学调查显示感染率为4.0%，这表明该市可能发生了1123例圣路易斯脑炎疫情感染。在对该病毒有中和抗体但无特异性IgM的调查受访者中，11.2%的人有既往圣路易斯脑炎病毒感染证据。圣路易斯脑炎病毒抗体的流行率与30年前进行的血清学调查中观察到的率相似，表明在此期间该市圣路易斯脑炎的地方性传播水平没有明显变化。
