Ylikorkala O, Stenman U H, Halmesmäki E
Am J Obstet Gynecol. 1987 Aug;157(2):344-8. doi: 10.1016/s0002-9378(87)80168-0.
Serial measurements of gamma-glutamyl transferase and mean cell volume were done in 85 pregnant alcohol abusers (320 samples). These included 26 moderate drinkers, 30 heavy drinkers, and 29 alcoholic women. Studies of 28 pregnant women who denied the use of alcohol (138 samples) showed that pregnancy itself had no effect on gamma-glutamyl transferase and mean cell volume. However, gamma-glutamyl transferase was increased in 14.9%, 31.7% and 59.1% of the samples collected from moderate drinkers, heavy drinkers, and alcoholic women, respectively, and likewise mean cell volume was elevated in 10.8%, 17.2%, and 40.2%, respectively. Either gamma-glutamyl transferase or mean cell volume was high or both were high in 27.1% of the moderate drinkers, in 38.3% of the heavy drinkers, and in 76.3% of the alcoholic women. Fetal alcohol effects developed in 42 cases. Increased gamma-glutamyl transferase predicted fetal alcohol effects in 61.5%, with a relative risk of 2.51. Elevated mean cell volume predicted fetal alcohol effects in 40.9%, with a relative risk of 2.40. These results suggest that the assay of gamma-glutamyl transferase and mean cell volume can be valuable in monitoring pregnant women with recognized or suspected alcohol abuse.
对85名孕期酗酒者（共320份样本）进行了γ-谷氨酰转移酶和平均红细胞体积的系列测量。其中包括26名中度饮酒者、30名重度饮酒者和29名酗酒女性。对28名否认饮酒的孕妇（138份样本）的研究表明，妊娠本身对γ-谷氨酰转移酶和平均红细胞体积没有影响。然而，分别从中度饮酒者、重度饮酒者和酗酒女性采集的样本中，γ-谷氨酰转移酶升高的比例分别为14.9%、31.7%和59.1%，同样，平均红细胞体积升高的比例分别为10.8%、17.2%和40.2%。在中度饮酒者中，27.1%的样本γ-谷氨酰转移酶或平均红细胞体积升高或两者均升高；在重度饮酒者中，这一比例为38.3%；在酗酒女性中，为76.3%。42例出现了胎儿酒精效应。γ-谷氨酰转移酶升高预测胎儿酒精效应的准确率为61.5%，相对风险为2.51。平均红细胞体积升高预测胎儿酒精效应的准确率为40.9%，相对风险为2.40。这些结果表明，γ-谷氨酰转移酶和平均红细胞体积的检测对于监测已确认或疑似酗酒的孕妇可能具有重要价值。
