Larsson G, Ottenblad C, Hagenfeldt L, Larsson A, Forsgren M
Am J Obstet Gynecol. 1983 Nov 15;147(6):654-7. doi: 10.1016/0002-9378(83)90444-1.
Serum gamma-glutamyl transferase was analyzed in 669 pregnant women. They were interviewed with special emphasis on their consumption of alcohol during the first trimester. Thirteen percent admitted a consumption of greater than 30 gm of pure alcohol per day, and 3%, greater than 125 gm per day. One child with a complete fetal alcohol syndrome and one with a partial one were born to mothers with a high consumption of alcohol and elevated serum gamma-glutamyl transferase. The ninety-fifth percentile for serum gamma-glutamyl transferase in women classified as low consumers (less than 30 gm of alcohol per day) was 0.44 mukat/L. With this 95% specificity level used as a cutoff, the sensitivity of the serum gamma-glutamyl transferase test in identifying those who consumed more than 30 gm of alcohol per day was 25%. The conclusion was that screening based on analyses of serum gamma-glutamyl transferase is not to be recommended for routine use in prenatal care.
对669名孕妇进行了血清γ-谷氨酰转移酶分析。对她们进行了访谈，特别关注她们在孕早期的酒精摄入量。13%的孕妇承认每天饮用超过30克纯酒精，3%的孕妇每天饮用超过125克。两名酒精摄入量高且血清γ-谷氨酰转移酶升高的母亲分别生下了一名患有完全胎儿酒精综合征的儿童和一名患有部分胎儿酒精综合征的儿童。在被归类为低酒精消费者（每天饮用少于30克酒精）的女性中，血清γ-谷氨酰转移酶的第95百分位数为0.44微卡特/升。以这个95%的特异性水平作为临界值，血清γ-谷氨酰转移酶检测在识别那些每天饮用超过30克酒精的人时的敏感性为25%。结论是，不建议在产前护理中常规使用基于血清γ-谷氨酰转移酶分析的筛查方法。
