Sağlam Dilek, Bilgici Meltem Ceyhan, Kara Cengiz, Yılmaz Gülay Can, Çamlıdağ İlkay
1 Department of Radiology, Ondokuz Mayıs University, School of Medicine, 55270 Kurupelit, Samsun, Turkey.
2 Department of Pediatrics, Ondokuz Mayıs University, School of Medicine, Samsun, Turkey.
AJR Am J Roentgenol. 2017 Nov;209(5):1143-1149. doi: 10.2214/AJR.17.18170. Epub 2017 Sep 5.
The aim of this study is to determine the effects of type 1 diabetes on pancreas and kidney elasticity in children, using acoustic radiation force impulse ultrasound elastography.
Sixty autoantibody-positive patients with type 1 diabetes (45% girls; mean [± SD] age, 11.7 ± 4.4 years; range, 1.9-19.3 years) admitted to the pediatric endocrinology outpatient clinic and 32 healthy children (50% girls; mean age, 10.2 ± 3.8 years; range, 2.1-17.3 years) were included in the study. Acoustic radiation force impulse elastography measurements were performed of the kidneys and pancreas in both groups. Body mass index, duration of diabetes, HbA1c levels, and insulin dosage of patients with type 1 diabetes were recorded.
The mean shear-wave velocities of the pancreas were 0.99 ± 0.25 m/s in patients with type 1 diabetes and 1.09 ± 0.22 m/s in healthy control subjects; the difference was not significant (p = 0.08). The median shear-wave velocities of the right and left kidneys in patients with type 1 diabetes were 2.43 ± 0.29 and 2.47 ± 0.25 m/s, respectively. There were no significant differences in the shear-wave velocities of the right and left kidneys between the patients with type 1 diabetes and the healthy control subjects (p = 0.91 and p = 0.73, respectively). Correlation analysis showed no correlation between the shear-wave velocities of the pancreas and kidney versus HbA1c level, duration of diabetes, insulin dosage, height, weight, and body mass index of the patients with type 1 diabetes.
The current study showed no significant difference in the shear-wave velocity of kidneys in children with type 1 diabetes with normoalbuminuria compared with the healthy control subjects. We also observed that the shear-wave velocity of the pancreas in children with type 1 diabetes and healthy control subjects did not differ significantly.
本研究旨在利用声辐射力脉冲超声弹性成像技术，确定1型糖尿病对儿童胰腺和肾脏弹性的影响。
纳入60例儿科内分泌门诊收治的自身抗体阳性的1型糖尿病患者（45%为女孩；平均[±标准差]年龄为11.7±4.4岁；范围为1.9 - 19.3岁）以及32名健康儿童（50%为女孩；平均年龄为10.2±3.8岁；范围为2.1 - 17.3岁）。对两组的肾脏和胰腺进行声辐射力脉冲弹性成像测量。记录1型糖尿病患者的体重指数、糖尿病病程、糖化血红蛋白水平及胰岛素剂量。
1型糖尿病患者胰腺的平均剪切波速度为0.99±0.25米/秒，健康对照者为1.09±0.22米/秒；差异无统计学意义（p = 0.08）。1型糖尿病患者右肾和左肾的中位剪切波速度分别为2.43±0.29和2.47±0.25米/秒。1型糖尿病患者与健康对照者的右肾和左肾剪切波速度差异均无统计学意义（分别为p = 0.91和p = 0.73）。相关性分析显示，1型糖尿病患者胰腺和肾脏的剪切波速度与糖化血红蛋白水平、糖尿病病程、胰岛素剂量、身高、体重及体重指数之间均无相关性。
本研究表明，与健康对照者相比，尿白蛋白正常的1型糖尿病儿童的肾脏剪切波速度无显著差异。我们还观察到，1型糖尿病儿童与健康对照者的胰腺剪切波速度也无显著差异。
