Sağlam Dilek, Ceyhan Bilgici Meltem, Kara Cengiz, Can Yilmaz Gülay, Tanrivermiş Sayit Asli
Departments of *Radiology, and †Pediatric Endocrinology, School of Medicine, Ondokuz Mayis University, Atakum, Samsun, Turkey.
Ultrasound Q. 2017 Sep;33(3):225-228. doi: 10.1097/RUQ.0000000000000301.
The aim of this study is to evaluate the shear wave velocity (SWV) of the thyroid gland with acoustic radiation force impulse elastography in children with type 1 diabetes mellitus (T1D).
Between November 2015 and April 2016, 35 T1D patients who were referred to our hospital's endocrinology outpatient clinic (mean age, 11.88 ± 4.1 years) and 30 children (mean age, 11.3 ± 3.08 years) in the control group were enrolled in the study. Five acoustic radiation force impulse elastography measurements from each lobe of the thyroid gland in m/s were recorded. Diabetes age, hemoglobin A1c, and C-peptide levels were recorded in T1D patients. Statistical analyses were performed using SPSS version 21 (IBM Corporation, Armonk, NY).
The mean SWV of the thyroid gland in T1D patients and the control group was 1.11 ± 0.21 and 1.29 ± 0.23 m/s, respectively. The mean SWV of the thyroid gland in T1D patients was lower than that in the control group and this was significant (P = 0.002). The mean SWV of the thyroid gland was not correlated with hemoglobin A1c level, body mass index, or the insulin dose in T1D patients.
The present study showed that T1D affects the thyroid gland stiffness even in patients without autoimmune thyroiditis. Acoustic radiation force impulse elastography may be a useful method in determining early changes in thyroid gland in T1D and may be used as a screening tool.
本研究旨在通过声辐射力脉冲弹性成像技术评估1型糖尿病（T1D）患儿甲状腺的剪切波速度（SWV）。
2015年11月至2016年4月，35例转诊至我院内分泌门诊的T1D患者（平均年龄11.88±4.1岁）和30例对照组儿童（平均年龄11.3±3.08岁）纳入本研究。记录甲状腺每个叶以米/秒为单位的五次声辐射力脉冲弹性成像测量值。记录T1D患者的糖尿病病程、糖化血红蛋白和C肽水平。使用SPSS 21版（IBM公司，纽约州阿蒙克）进行统计分析。
T1D患者和对照组甲状腺的平均SWV分别为1.11±0.21米/秒和1.29±0.23米/秒。T1D患者甲状腺的平均SWV低于对照组，差异有统计学意义（P = 0.002）。T1D患者甲状腺的平均SWV与糖化血红蛋白水平、体重指数或胰岛素剂量无关。
本研究表明，即使在没有自身免疫性甲状腺炎的患者中，T1D也会影响甲状腺硬度。声辐射力脉冲弹性成像可能是确定T1D患者甲状腺早期变化的有用方法，可作为一种筛查工具。
