Desvignes Catherine, Dabadie Alexia, Aschero Audrey, Ruocco Alix, Garaix Florentine, Daniel Laurent, Ferlicot Sophie, Villes Virginie, Loundou Anderson D, Gorincour Guillaume, Petit Philippe
Department of Pediatric and Prenatal Imaging, La Timone Children Hospital, Marseille, France.
Department of Radiology, Fondation Hôpital Saint Joseph, Marseille, France.
Pediatr Radiol. 2021 Sep;51(10):1879-1888. doi: 10.1007/s00247-021-05068-x. Epub 2021 Apr 24.
Ultrasound elastography has been suggested for assessing organ fibrosis.
To study the feasibility of shear-wave elastography in children with kidney disease and the correlation between elasticity and kidney fibrosis in order to reduce the indications for kidney biopsy and its complications.
Four operators measured kidney elasticity in children with kidney diseases or transplants, all of whom also had a renal biopsy. We assessed the feasibility and the intraobserver variability of the elasticity measurements for each probe used and each kidney explored. Then we tested the correlation between elasticity measurements and the presence of fibrosis.
Overall, we analyzed 95 children and adolescents, 31 of whom had renal transplant. Measurements with the convex probe were possible in 100% of cases. Linear probe analysis was only possible for 20% of native kidneys and 50% of transplants. Intraobserver variabilities ranged from moderate to high, depending on the probe and kidney studied. Elasticity was higher with the linear probe than with the convex probe (P<0.001 for left kidney and P=0.03 for right kidney). Measurements did not differ from one kidney to another in the same child. Elasticity and fibrosis were both higher in transplant patients (P=0.02 with convex probe; P=0.01 with linear probe; P=0.04 overall). There was no correlation between elasticity and fibrosis.
Of the devices used in this work, kidney elastography was more accurately analyzed with a convex probe. Our study did not identify any correlation between elasticity and kidney fibrosis.
超声弹性成像已被用于评估器官纤维化。
研究剪切波弹性成像在肾病患儿中的可行性以及弹性与肾纤维化之间的相关性，以减少肾活检的指征及其并发症。
四名操作者对患有肾病或接受肾移植的儿童进行肾脏弹性测量，所有患儿均接受了肾活检。我们评估了每种使用的探头和每个探查肾脏的弹性测量的可行性和观察者内变异性。然后我们测试了弹性测量与纤维化存在之间的相关性。
总体而言，我们分析了95名儿童和青少年，其中31人接受了肾移植。100%的病例可以使用凸阵探头进行测量。线性探头分析仅在20%的天然肾和50%的移植肾中可行。观察者内变异性从中度到高度不等，取决于所研究的探头和肾脏。线性探头测量的弹性高于凸阵探头（左肾P<0.001，右肾P=0.03）。同一患儿的两侧肾脏测量结果无差异。移植患者的弹性和纤维化均较高（凸阵探头P=0.02；线性探头P=0.01；总体P=0.04）。弹性与纤维化之间无相关性。
在本研究使用的设备中，使用凸阵探头对肾脏弹性成像进行分析更为准确。我们的研究未发现弹性与肾纤维化之间存在任何相关性。
