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小儿持续性阻塞性睡眠呼吸暂停的舌扁桃体切除术:一项系统评价和荟萃分析

Lingual Tonsillectomy for Pediatric Persistent Obstructive Sleep Apnea: A Systematic Review and Meta-analysis.

作者信息

Rivero Alexander, Durr Megan

机构信息

1 Kaiser Permanente, Oakland, California, USA.

出版信息

Otolaryngol Head Neck Surg. 2017 Dec;157(6):940-947. doi: 10.1177/0194599817725708. Epub 2017 Sep 5.

Abstract

Objective To determine the role of lingual tonsillectomy (LT) in pediatric patients with persistent obstructive sleep apnea (OSA) after tonsillectomy and adenoidectomy (T&A). Data Sources PubMed, OVID-MEDLINE, and Cochrane Central from 2006 to 2017. Review Methods Inclusion criteria included English-language studies containing original data on LT in pediatric patients with persistent OSA. Exclusion criteria included case reports and studies without outcome measures. Two investigators independently reviewed all manuscripts and performed quality assessment using validated tools. Meta-analysis was performed. Results Of the 866 abstracts identified, 5 studies met inclusion criteria. All studies were case series (level of evidence 4). Outcome measures included apnea-hypopnea index (AHI), minimum oxygen saturation (minSaO), comorbidity status, and adverse events. Qualitatively, all studies demonstrated reduction in AHI and increase in minSaO after LT. Comorbidities may not affect the success of LT for lingual tonsil hypertrophy (LTH). LT had similar adverse event rates as T&A. Meta-analysis was performed on 4 studies. LT showed a mean change in reduction of AHI and increase of minSaO of -6.64 (95% CI, -8.63 to -4.65) and 4.17 (95% CI, 1.25-7.08), respectively. The overall success rate, defined as postoperative AHI <5, was 52%. Conclusion LT for LTH can be a safe and effective adjunct surgery for persistent OSA in patients after T&A. LT may reduce AHI and increase minSaO, though complete resolution of OSA is rare. Given the limited number of patients studied, no formal recommendations can be made for the routine use of LT for LTH in persistent pediatric OSA.

摘要

目的 确定舌扁桃体切除术(LT)在扁桃体切除术和腺样体切除术(T&A)后仍患有持续性阻塞性睡眠呼吸暂停(OSA)的儿科患者中的作用。数据来源 2006年至2017年的PubMed、OVID-MEDLINE和Cochrane Central。综述方法 纳入标准包括包含持续性OSA儿科患者LT原始数据的英文研究。排除标准包括病例报告和无结局指标的研究。两名研究者独立审查所有手稿,并使用经过验证的工具进行质量评估。进行荟萃分析。结果 在识别出的866篇摘要中,5项研究符合纳入标准。所有研究均为病例系列(证据级别4)。结局指标包括呼吸暂停低通气指数(AHI)、最低血氧饱和度(minSaO)、合并症状态和不良事件。定性分析显示,所有研究均表明LT术后AHI降低,minSaO升高。合并症可能不影响LT治疗舌扁桃体肥大(LTH)的成功率。LT的不良事件发生率与T&A相似。对4项研究进行了荟萃分析。LT显示AHI降低和minSaO升高的平均变化分别为-6.64(95%CI,-8.63至-4.65)和4.17(95%CI,1.25 - 7.08)。定义为术后AHI<5的总体成功率为52%。结论 对于T&A后持续性OSA患者,LTH的LT可以是一种安全有效的辅助手术。LT可能降低AHI并提高minSaO,尽管OSA完全缓解很少见。鉴于研究的患者数量有限,无法对持续性儿科OSA中LTH常规使用LT做出正式推荐。

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