小儿阻塞性睡眠呼吸暂停:诊断挑战与管理策略

Pediatric Obstructive Sleep Apnea: Diagnostic Challenges and Management Strategies.

作者信息

Gupta Surendra, Sharma Rakesh

机构信息

Pediatrics, Clinica Sierra Vista, Fresno, USA.

Pediatrics, Neoclinic Children Hospital, Jaipur, IND.

出版信息

Cureus. 2024 Dec 8;16(12):e75347. doi: 10.7759/cureus.75347. eCollection 2024 Dec.

Abstract

Pediatric obstructive sleep apnea (OSA) is a prevalent yet often underdiagnosed condition affecting 1-5% of children globally, with higher prevalence in populations such as those with Down syndrome and obesity. Characterized by recurrent upper airway obstruction during sleep, OSA can lead to serious health consequences, including neurocognitive deficits, behavioral issues, and cardiovascular complications. The diagnosis is complicated by symptom overlap with conditions like Attention-Deficit/Hyperactivity Disorder (ADHD) while polysomnography (PSG) remains the gold standard for diagnosis, access to this test is limited in many regions. Treatment options include lifestyle modifications, surgical interventions like adenotonsillectomy, and non-invasive approaches such as upper airway stenting for patients who are non-compliant with continuous positive airway pressure (CPAP) therapy. Evidence indicates that adenotonsillectomy significantly reduces the apnea-hypopnea index (AHI) in children with adenotonsillar hypertrophy, although residual OSA is common, particularly in high-risk populations like those with Prader-Willi syndrome. Recent studies have explored pharmacological treatments, advanced diagnostic techniques, and machine learning applications to improve outcomes. This review emphasizes the importance of a multidisciplinary, individualized approach to the management of pediatric OSA, highlighting the need for further research into innovative therapeutic strategies and long-term outcomes for affected children.

摘要

小儿阻塞性睡眠呼吸暂停(OSA)是一种普遍存在但常常诊断不足的疾病,全球1%-5%的儿童受其影响,在唐氏综合征和肥胖症患者等人群中患病率更高。OSA的特征是睡眠期间反复出现上呼吸道阻塞,可导致严重的健康后果,包括神经认知缺陷、行为问题和心血管并发症。由于症状与注意力缺陷多动障碍(ADHD)等疾病重叠,诊断较为复杂,而多导睡眠图(PSG)仍然是诊断的金标准,但在许多地区,进行这项检查的机会有限。治疗选择包括生活方式改变、腺样体扁桃体切除术等手术干预措施,以及针对不依从持续气道正压通气(CPAP)治疗的患者的无创方法,如气道支架置入。有证据表明,腺样体扁桃体切除术可显著降低腺样体扁桃体肥大儿童的呼吸暂停低通气指数(AHI),尽管残余OSA很常见,尤其是在普拉德-威利综合征等高危人群中。最近的研究探索了药物治疗、先进的诊断技术和机器学习应用,以改善治疗效果。本综述强调了采用多学科、个体化方法管理小儿OSA的重要性,强调需要进一步研究创新治疗策略以及受影响儿童的长期治疗效果。

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