Novelli A, Henneberry R C
Brain Res. 1987 Aug;431(2):307-10. doi: 10.1016/0165-3806(87)90219-7.
Sensitivity of cyclic GMP synthesis to stimulation by excitatory amino acids, depolarizing agents, and divalent cation ionophores develops during the differentiation of cerebellar neurons in culture; in each case calcium influx appears responsible for activating guanylate cyclase. The developmental event being followed is not the appearance of either the soluble or the particulate form of the enzyme since both are present throughout. The possible role of a differentiation-dependent calcium-modulating protein is discussed.
在培养的小脑神经元分化过程中，环鸟苷酸（cGMP）合成对兴奋性氨基酸、去极化剂和二价阳离子离子载体刺激的敏感性逐渐形成；在每种情况下，钙内流似乎都负责激活鸟苷酸环化酶。所追踪的发育事件并非该酶的可溶性或颗粒性形式的出现，因为这两种形式始终都存在。文中还讨论了一种依赖分化的钙调节蛋白的可能作用。
