Akbar Nadine, Signori Alessio, Amato Maria Pia, Sormani Maria Pia, Portaccio Emilio, Niccolai Claudia, Goretti Benedetta, Till Christine, Banwell Brenda
a School of Rehabilitation Therapy , Queen's University , Kingston , Ontario , Canada.
b Department of Health Sciences (DISSAL) , University of Genoa , Genoa , Italy.
Dev Neuropsychol. 2017;42(5):299-308. doi: 10.1080/87565641.2017.1351974. Epub 2017 Sep 5.
Processing speed is a frequently affected cognitive domain in pediatric multiple sclerosis (MS) and is commonly assessed using the Symbol Digit Modalities Test (SDMT). The objective of this study was to determine maturational trajectories in SDMT performance and baseline factors affecting trajectories in a sample of 82 pediatric MS individuals. Performance on the SDMT increased with age in patients with pediatric MS followed by a subsequent decline. Furthermore, patients who were older at disease onset and had a higher IQ showed greater gains with age, suggesting that these factors may be protective with respect to cognitive maturation in pediatric MS.
处理速度是小儿多发性硬化症（MS）中经常受到影响的认知领域，通常使用符号数字模态测试（SDMT）进行评估。本研究的目的是确定82名小儿MS患者样本中SDMT表现的成熟轨迹以及影响轨迹的基线因素。小儿MS患者的SDMT表现随年龄增长而增加，随后下降。此外，疾病发作时年龄较大且智商较高的患者随年龄增长表现出更大的进步，这表明这些因素可能对小儿MS的认知成熟具有保护作用。
