Carey R M, Hughes J M
Clin Exp Hypertens A. 1987;9(5-6):1009-20. doi: 10.3109/10641968709161462.
The selective dopamine-1 (DA-1) receptor agonist, fenoldopam, was studied during intravenous administration to ten normal male subjects on a diet of 150 mEq sodium and 60 mEq potassium per day to determine the mechanism of dopamine-induced natriuresis. During DA-1 receptor stimulation, urine flow rate and renal plasma flow manifested a biphasic increase. Urine flow rate increased from a control of 13 +/- 1 to 17 +/- 1.2 ml/min and again to a peak of 16 +/- 1. Renal plasma flow increased from 344 +/- 39 to 481 +/- 44 ml/min and then to 497 +/- 38. Sodium excretion (UNaV) and fractional sodium excretion (FENa) demonstrated a sustained increase. UNaV rose from a control of 0.21 +/- 0.03 to 0.32 +/- 0.05 mEq/min. FENa rose from a control of 1.6 +/- 0.1 to 2.7 +/- 0.6%. Fenoldopam did not alter glomerular filtration rate. The association of changes in renal plasma flow and in UNaV and FENa demonstrate in man that DA-1 receptor stimulation causes natriuresis by direct renal tubular action. The renal tubular effect appears to be a major determinant of the degree of natriuresis.
在对10名每天摄入150毫当量钠和60毫当量钾饮食的正常男性受试者进行静脉给药期间，研究了选择性多巴胺-1（DA-1）受体激动剂非诺多泮，以确定多巴胺诱导利钠作用的机制。在DA-1受体刺激期间，尿流率和肾血浆流量呈双相增加。尿流率从对照值13±1毫升/分钟增加到17±1.2毫升/分钟，然后再次达到峰值16±1毫升/分钟。肾血浆流量从344±39毫升/分钟增加到481±44毫升/分钟，然后增加到497±38毫升/分钟。钠排泄量（UNaV）和钠排泄分数（FENa）持续增加。UNaV从对照值0.21±0.03毫当量/分钟升至0.32±0.05毫当量/分钟。FENa从对照值1.6±0.1%升至2.7±0.6%。非诺多泮未改变肾小球滤过率。肾血浆流量以及UNaV和FENa的变化之间的关联表明，在人体中，DA-1受体刺激通过直接肾小管作用导致利钠作用。肾小管效应似乎是利钠程度的主要决定因素。
