Hughes J M, Beck T R, Rose C E, Carey R M
J Hypertens Suppl. 1986 Dec;4(6):S106-8.
Fenoldopam mesylate, a selective dopamine-1 (DA-1) receptor agonist, was infused intravenously in 10 normal male subjects in metabolic balance. The study was designed to determine the mechanism of dopamine-induced natriuresis. During fenoldopam infusion renal plasma flow (RPF) and urine flow rate manifested a biphasic response. The RPF rose from 344 +/- 39 to 481 +/- 44 ml/min (P less than 0.05), decreased to control levels, and then rose to 497 +/- 38 ml/min (P less than 0.05). Urinary sodium excretion (UNaV) and fractional excretion of sodium (FENa) demonstrated a sustained increase during DA-1 receptor activation. The FENa rose from 1.6 +/- 0.1 to 2.7 +/- 0.6% (P less than 0.05). Glomerular filtration rate (GFR), blood pressure and heart rate were unchanged. Our results, specifically the dissociation of RPF from UNaV and FENa, demonstrate in man that stimulation of renal tubular DA-1 receptors causes natriuresis.
甲磺酸非诺多泮是一种选择性多巴胺 -1（DA -1）受体激动剂，对10名处于代谢平衡状态的正常男性受试者进行静脉输注。该研究旨在确定多巴胺诱导利钠作用的机制。在输注甲磺酸非诺多泮期间，肾血浆流量（RPF）和尿流率表现出双相反应。RPF从344±39毫升/分钟升至481±44毫升/分钟（P<0.05），随后降至对照水平，然后又升至497±38毫升/分钟（P<0.05）。在DA -1受体激活期间，尿钠排泄量（UNaV）和钠分数排泄量（FENa）持续增加。FENa从1.6±0.1%升至2.7±0.6%（P<0.05）。肾小球滤过率（GFR）、血压和心率未发生变化。我们的研究结果，特别是RPF与UNaV和FENa的分离，在人体中证明了肾小管DA -1受体的刺激会导致利钠作用。
