Berntorp E, Berntorp K, Seiving B, Stenberg P
Diabetes Res. 1987 May;5(1):29-33.
A method for capping of beta 2-microglobulin involving the transglutaminase inhibitor monodansylthiacadaverine was applied to lymphocytes from 17 patients with Type 2 diabetes mellitus and from a matched control group of 16 normoglycaemic healthy subjects. Monodansylthiacadaverine strongly inhibited the capping, which points to the involvement of transglutaminase in the redistribution of beta 2-microglobulin on the cell surface. The inhibition was more pronounced in lymphocytes from diabetic patients, indicating impaired transglutaminase function in Type 2 diabetes mellitus.
一种涉及转谷氨酰胺酶抑制剂单丹磺酰硫代尸胺的β2-微球蛋白封帽方法应用于17例2型糖尿病患者及16例血糖正常的健康对照者的淋巴细胞。单丹磺酰硫代尸胺强烈抑制封帽，这表明转谷氨酰胺酶参与了β2-微球蛋白在细胞表面的重新分布。这种抑制在糖尿病患者的淋巴细胞中更为明显，表明2型糖尿病中转谷氨酰胺酶功能受损。
