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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sedrani S H, el-Banna A A

Comp Biochem Physiol A Comp Physiol. 1987;87(3):635-9. doi: 10.1016/0300-9629(87)90374-4.

Inhibition of prostaglandin (PG) synthesis by indomethacin (Id) during early pregnancy in rabbits apparently disrupts the process of sex steroid production by the ovaries. 2. The role of PGs as mediators in steroidogenesis was tested by investigating the effect of Id alone or in combination with progesterone, with oestradiol and progesterone, or with a mixture of PGs, on plasma levels of 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) in rabbits at an early stage of pregnancy. 3. Id alone significantly reduced plasma levels of both 25(OH) D and 1,25(OH)2D. Treatment with Id in combination with either oestradiol and progesterone, or with a mixture of PGs, resulted in the restoration of plasma levels of both vitamin D metabolites as well as the restoration of plasma levels of progesterone, to their control values.

妊娠早期给家兔注射消炎痛（Id）抑制前列腺素（PG）合成，显然会干扰卵巢甾体激素的产生过程。2. 通过研究单独使用Id或Id与孕酮、雌二醇和孕酮联合使用，或与PG混合物联合使用，对妊娠早期家兔血浆中25-羟维生素D（25(OH)D）和1,25-二羟维生素D（1,25(OH)2D）水平的影响，来测试PGs作为甾体激素生成介质的作用。3. 单独使用Id会显著降低血浆中25(OH)D和1,25(OH)2D的水平。Id与雌二醇和孕酮联合使用，或与PG混合物联合使用，可使两种维生素D代谢物的血浆水平以及孕酮的血浆水平恢复到对照值。

Sedrani S H, el-Banna A A

Comp Biochem Physiol A Comp Physiol. 1987;87(3):635-9. doi: 10.1016/0300-9629(87)90374-4.

Inhibition of prostaglandin (PG) synthesis by indomethacin (Id) during early pregnancy in rabbits apparently disrupts the process of sex steroid production by the ovaries. 2. The role of PGs as mediators in steroidogenesis was tested by investigating the effect of Id alone or in combination with progesterone, with oestradiol and progesterone, or with a mixture of PGs, on plasma levels of 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) in rabbits at an early stage of pregnancy. 3. Id alone significantly reduced plasma levels of both 25(OH) D and 1,25(OH)2D. Treatment with Id in combination with either oestradiol and progesterone, or with a mixture of PGs, resulted in the restoration of plasma levels of both vitamin D metabolites as well as the restoration of plasma levels of progesterone, to their control values.

妊娠早期给家兔注射消炎痛（Id）抑制前列腺素（PG）合成，显然会干扰卵巢甾体激素的产生过程。2. 通过研究单独使用Id或Id与孕酮、雌二醇和孕酮联合使用，或与PG混合物联合使用，对妊娠早期家兔血浆中25-羟维生素D（25(OH)D）和1,25-二羟维生素D（1,25(OH)2D）水平的影响，来测试PGs作为甾体激素生成介质的作用。3. 单独使用Id会显著降低血浆中25(OH)D和1,25(OH)2D的水平。Id与雌二醇和孕酮联合使用，或与PG混合物联合使用，可使两种维生素D代谢物的血浆水平以及孕酮的血浆水平恢复到对照值。