吲哚美辛对狨猴卵巢在体内前列腺素和类固醇合成的影响。
Effect of indomethacin on prostaglandin and steroid synthesis by the marmoset ovary in vivo.
作者信息
Barbosa I, Maia H, Lopes T, Elder M G, Coutinho E M
出版信息
Int J Fertil. 1979;24(2):142-4.
PMID:40910
Abstract
Indomethacin decreased Prostaglandin F 2 alpha levels in the ovaries of marmoset monkeys which were treated with PMS/HCG. The production of estradiol and progesterone, however, was unaffected by the blockade in prostaglandin synthesis. The number of ovulations following PMS/HCG treatment was significantly reduced by indomethacin treatment. These observations suggest that prostaglandins are required for follicular rupture but not for progesterone and estradiol production by the ovary.
摘要
吲哚美辛降低了用孕马血清促性腺激素/人绒毛膜促性腺激素处理的狨猴卵巢中前列腺素F 2α的水平。然而，雌二醇和孕酮的产生不受前列腺素合成阻断的影响。吲哚美辛处理显著减少了孕马血清促性腺激素/人绒毛膜促性腺激素处理后的排卵数。这些观察结果表明，前列腺素是卵泡破裂所必需的，但不是卵巢产生孕酮和雌二醇所必需的。
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