炎症：健康与疾病中造血干细胞命运的关键调节因子。
Inflammation: a key regulator of hematopoietic stem cell fate in health and disease.
作者信息
Pietras Eric M
机构信息
Division of Hematology, Department of Medicine, and Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
出版信息
Blood. 2017 Oct 12;130(15):1693-1698. doi: 10.1182/blood-2017-06-780882. Epub 2017 Sep 5.
Abstract
Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute needs such as infection or injury. Significant interest has emerged in how inflammation regulates HSC fate and how it affects the long-term functionality of HSCs and the blood system as a whole. Here we detail recent advances and unanswered questions at the intersection between inflammation and HSC biology in the contexts of development, aging, and hematological malignancy.
摘要
造血干细胞（HSCs）负责血细胞的终身生成。与此同时，它们必须对感染或损伤等急性需求迅速做出反应。炎症如何调节造血干细胞命运，以及它如何影响造血干细胞和整个血液系统的长期功能，已引起了人们极大的兴趣。在这里，我们详细阐述了在发育、衰老和血液系统恶性肿瘤背景下，炎症与造血干细胞生物学交叉领域的最新进展和未解决的问题。
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