造血干细胞的炎性衰老
Inflamm-aging of hematopoietic stem cells.
作者信息
Chen Zhiyang, Ju Zhenyu
机构信息
Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China.
出版信息
Blood Sci. 2019 Oct 21;1(2):141-143. doi: 10.1097/BS9.0000000000000029. eCollection 2019 Oct.
Hematopoietic stem cells (HSCs) are responsible for generating all blood cells throughout life. Apart from the role of HSCs in maintaining the homeostasis of blood cell production process, they must respond quickly to hematopoietic challenges, such as infection or blood loss. HSCs can be directly/indirectly activated and engage in blood formation for the acute needs in response to inflammation. Recent findings highlight the emerging role of inflammation signaling on HSC fate decision and shaping the hematopoietic system during aging. Here, we summarize recent studies identifying the changes in inflammation and their role in modulation of HSC function and discuss the interaction between inflammation and HSC biology in the contexts of aging and hematological malignancy.
造血干细胞（HSCs）负责在整个生命过程中产生所有血细胞。除了造血干细胞在维持血细胞生成过程的稳态中的作用外，它们还必须对造血挑战迅速做出反应，例如感染或失血。造血干细胞可以被直接/间接激活，并参与造血以满足炎症反应中的急性需求。最近的研究结果突出了炎症信号在造血干细胞命运决定以及衰老过程中塑造造血系统方面的新作用。在这里，我们总结了最近确定炎症变化及其在调节造血干细胞功能中的作用的研究，并讨论了在衰老和血液系统恶性肿瘤背景下炎症与造血干细胞生物学之间的相互作用。
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