• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抑制血管生成：百里香的一种新作用。

Inhibition of Angiogenesis: A Novel Effect of Zataria Multiflora.

作者信息

Norooznezhad Amir Hossein, Keshavarz Maryam, Norooznezhad Fatemeh, Mansouri Kamran

机构信息

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Int J Hematol Oncol Stem Cell Res. 2017 Apr 1;11(2):96-101.

PMID:28875003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5575732/
Abstract

Angiogenesis, the formation of new blood vessels from preexisting ones, is among the most important physiological and pathological processes that occur in the body. Under pathological conditions such as tumor growth, psoriasis, corneal neovascularization and rheumatoid arthritis, angiogenesis is substantial for the development of the disease. Zataria multiflora is a member of the Labiatae family with a vast range of traditional uses which has been long known and applied in Iran old medicine. The aim of this study was the evaluation of anti-angiogenic potential of Zataria multiflora. In this study, human umbilical vein endothelial cells (HUVECs) were isolated from newborn umbilical veins and then cultured for cytotoxicity (LDH test) assay. Regarding LDH results, following tests such as angiogenesis (cytodex-3 micro carrier) and migration (wound healing) tests were designed. The cytotoxicity assays showed no toxicity of Z.multiflora toward HUVECs in the range of 10-450µg/mL of the extract. This extract was also able to inhibit angiogenesis and migration at 200µg/mL. Our data clearly demonstrated an inhibitory effect of Z. multiflora on angiogenesis and migration of HUVECs. Z. multiflora could be introduced as a significant angiogenesis inhibitor for angiogenesis-dependent diseases in further complementary studies.

摘要

血管生成，即从已有的血管形成新的血管，是身体中发生的最重要的生理和病理过程之一。在诸如肿瘤生长、银屑病、角膜新生血管形成和类风湿性关节炎等病理条件下，血管生成对疾病的发展至关重要。百里香是唇形科的一员，具有广泛的传统用途，在伊朗传统医学中早已为人所知并得到应用。本研究的目的是评估百里香的抗血管生成潜力。在本研究中，从新生儿脐静脉中分离出人脐静脉内皮细胞（HUVECs），然后进行细胞毒性（乳酸脱氢酶测试）测定。根据乳酸脱氢酶测试结果，设计了诸如血管生成（cytodex - 3微载体）和迁移（伤口愈合）测试等后续测试。细胞毒性测定表明，在提取物浓度为10 - 450μg/mL范围内，百里香对HUVECs无毒性。该提取物在200μg/mL时也能够抑制血管生成和迁移。我们的数据清楚地证明了百里香对HUVECs的血管生成和迁移具有抑制作用。在进一步的补充研究中，百里香可作为一种重要的血管生成抑制剂用于治疗血管生成依赖性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/3c1eef6b6432/IJHOSCR-11-96-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/141226da9a49/IJHOSCR-11-96-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/d06a6814374a/IJHOSCR-11-96-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/becdbc8678f2/IJHOSCR-11-96-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/6322cca820d3/IJHOSCR-11-96-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/733707e62754/IJHOSCR-11-96-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/3c1eef6b6432/IJHOSCR-11-96-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/141226da9a49/IJHOSCR-11-96-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/d06a6814374a/IJHOSCR-11-96-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/becdbc8678f2/IJHOSCR-11-96-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/6322cca820d3/IJHOSCR-11-96-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/733707e62754/IJHOSCR-11-96-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6937/5575732/3c1eef6b6432/IJHOSCR-11-96-g006.jpg

相似文献

1
Inhibition of Angiogenesis: A Novel Effect of Zataria Multiflora.抑制血管生成：百里香的一种新作用。
Int J Hematol Oncol Stem Cell Res. 2017 Apr 1;11(2):96-101.
2
Boiss. Essential Oil Induce Apoptosis in Two Human Colon Cancer Cell Lines (HCT116 & SW48).布瓦西。香精油诱导两种人结肠癌细胞系（HCT116和SW48）凋亡。
Iran J Public Health. 2020 Apr;49(4):753-762.
3
The effect of Boiss hydroalcoholic extract and fractions in pentylenetetrazole-induced kindling in mice.布瓦西水醇提取物及其馏分对戊四氮诱导的小鼠点燃效应的影响。
Avicenna J Phytomed. 2016 Nov-Dec;6(6):597-603.
4
In vitro anti-Candida Activity of Zataria multiflora Boiss.体外抗念珠菌活性的香薷
Evid Based Complement Alternat Med. 2007 Sep;4(3):351-3. doi: 10.1093/ecam/nel099.
5
The evaluation of Zataria multiflora Boiss. essential oil effect on biogenic amines formation and microbiological profile in Gouda cheese.百里香精油对高达干酪中生物胺形成及微生物状况的影响评估。
Lett Appl Microbiol. 2014 Dec;59(6):621-30. doi: 10.1111/lam.12319. Epub 2014 Oct 13.
6
Antibacterial activity of ethyl acetate and aqueous extracts of Mentha longifolia L. and hydroalcoholic extract of Zataria multiflora Boiss. plants against important human pathogens.长叶薄荷的乙酸乙酯提取物和水提取物以及多花百里香的水醇提取物对重要人类病原体的抗菌活性。
Asian Pac J Trop Med. 2014 Sep;7S1:S186-9. doi: 10.1016/S1995-7645(14)60229-7.
7
Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial.香薷对硫芥诱导的肺损伤患者血清细胞因子水平和肺功能的影响：一项随机双盲临床试验。
J Ethnopharmacol. 2020 Feb 10;248:112325. doi: 10.1016/j.jep.2019.112325. Epub 2019 Nov 9.
8
Management of acute cough by Zataria multiflora Boiss as an alternative treatment.用百里香作为替代疗法治疗急性咳嗽的管理。
J Integr Med. 2018 Jan;16(1):20-25. doi: 10.1016/j.joim.2017.12.006. Epub 2017 Dec 8.
9
The effect of extract on the clinical endometritis and reproductive indices in lactating Holstein dairy cows.提取物对泌乳期荷斯坦奶牛临床子宫内膜炎及繁殖指标的影响。
Vet Res Forum. 2016 Fall;7(4):309-315. Epub 2016 Dec 15.
10
Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti-inflammatory, antioxidant, and immunomodulatory effects.百里香及其成分的药理作用主要集中在其抗炎、抗氧化和免疫调节作用上。
Fundam Clin Pharmacol. 2018 Feb;32(1):26-50. doi: 10.1111/fcp.12331.

引用本文的文献

1
Angiogenesis: Biological Mechanisms and In Vitro Models.血管生成：生物学机制与体外模型
Ann Biomed Eng. 2025 Apr 10. doi: 10.1007/s10439-025-03721-2.
2
extract reverses lipopolysaccharide-induced anxiety and depression behaviors in rats.提取物可逆转大鼠中脂多糖诱导的焦虑和抑郁行为。
Avicenna J Phytomed. 2020 Jan-Feb;10(1):78-88.
3
Autophagy, cancer and angiogenesis: where is the link?自噬、癌症与血管生成：联系何在？

本文引用的文献

1
New function of TSGA10 gene in angiogenesis and tumor metastasis: a response to a challengeable paradox.TSGA10基因在血管生成和肿瘤转移中的新功能：对一个具有挑战性的矛盾现象的回应。
Hum Mol Genet. 2016 Jan 15;25(2):233-44. doi: 10.1093/hmg/ddv461. Epub 2015 Nov 15.
2
Next target of tranilast: inhibition of corneal neovascularization.曲尼司特的下一个目标：抑制角膜新生血管形成。
Med Hypotheses. 2014 Jun;82(6):700-2. doi: 10.1016/j.mehy.2014.03.007. Epub 2014 Mar 14.
3
Angiogenesis in cutaneous disease: part I.皮肤病中的血管生成：第一部分。
Cell Biosci. 2019 Aug 13;9:65. doi: 10.1186/s13578-019-0327-6. eCollection 2019.
4
ameliorates cisplatin-induced testicular damage via suppression of oxidative stress and apoptosis in a mice model.在小鼠模型中，通过抑制氧化应激和细胞凋亡改善顺铂诱导的睾丸损伤。
Iran J Basic Med Sci. 2018 Jun;21(6):607-614. doi: 10.22038/IJBMS.2018.26784.6558.
J Am Acad Dermatol. 2009 Dec;61(6):921-42; quiz 943-4. doi: 10.1016/j.jaad.2009.05.052.
4
Corneal neovascularization: molecular events and therapeutic options.角膜新生血管化：分子事件与治疗选择
Recent Pat Inflamm Allergy Drug Discov. 2009 Nov;3(3):221-31. doi: 10.2174/187221309789257450.
5
Angiogenesis and its targeting in rheumatoid arthritis.类风湿关节炎中的血管生成及其靶向治疗。
Vascul Pharmacol. 2009 Jul;51(1):1-7. doi: 10.1016/j.vph.2009.02.002. Epub 2009 Feb 13.
6
Angiogenesis: the new potential target for the therapy of psoriasis?血管生成：银屑病治疗的新潜在靶点？
Drug News Perspect. 2008 Mar;21(2):97-105. doi: 10.1358/dnp.2008.21.2.1188196.
7
In memoriam Dr. Judah Folkman.纪念犹大·福克曼博士。
Angiogenesis. 2008;11(1):1-2. doi: 10.1007/s10456-008-9103-7.
8
Anti-angiogenic effect of soybean kunitz trypsin inhibitor on human umbilical vein endothelial cells.大豆Kunitz胰蛋白酶抑制剂对人脐静脉内皮细胞的抗血管生成作用。
Fitoterapia. 2007 Dec;78(7-8):587-9. doi: 10.1016/j.fitote.2007.03.027. Epub 2007 May 25.
9
Cytotoxicity of some Russian ethnomedicinal plants and plant compounds.一些俄罗斯民族药用植物及植物化合物的细胞毒性
Phytother Res. 2005 May;19(5):428-32. doi: 10.1002/ptr.1616.
10
Low molecular weight fraction of shark cartilage can modulate immune responses and abolish angiogenesis.鲨鱼软骨的低分子量部分可调节免疫反应并抑制血管生成。
Int Immunopharmacol. 2005 Jun;5(6):961-70. doi: 10.1016/j.intimp.2005.01.006.