Li Long, Tan Tong-De, Zhang Ying-Qi, Liu Xin, Ye Long-Wu
State Key Laboratory of Physical Chemistry of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Org Biomol Chem. 2017 Oct 18;15(40):8483-8492. doi: 10.1039/c7ob01895a.
Isoxazoles, as masked 1,3-dicarbonyl equivalents, have proven to be versatile building blocks and pivotal intermediates for the construction of a variety of useful azacycles with molecular complexity. As a result, a range of new reactions have been discovered based on isoxazoles in the past decade. However, the relevant reactions of isoxazoles with alkynes have seldom been explored. In this review, we will focus on the recent progress in the transition-metal-catalyzed formal annulations for the efficient synthesis of N-heterocycles between alkynes and isoxazoles by highlighting their specificity and applicability, and the mechanistic rationale is presented where possible.
异恶唑作为一种掩蔽的1,3 - 二羰基等价物，已被证明是用于构建各种具有分子复杂性的有用氮杂环的通用结构单元和关键中间体。因此，在过去十年中基于异恶唑发现了一系列新反应。然而，异恶唑与炔烃的相关反应很少被研究。在本综述中，我们将重点关注过渡金属催化的炔烃与异恶唑之间高效合成氮杂环的形式环化反应的最新进展，突出其特异性和适用性，并尽可能给出反应机理的原理。
