Chen Fengjuan, Wang Yajun, Zhao Shijun, Jiang Wei, Huo Congde
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.
Org Biomol Chem. 2017 Sep 20;15(36):7710-7714. doi: 10.1039/c7ob01859b.
Catalytic amounts of TBHP (15 mol%) promoted tribromomethylation of activated alkenes has been developed. This method provided a metal-free aerobic way to construct tribromomethylated 2-oxindoles from the reaction of readily available N-arylacrylamides with CBrvia a proposed tandem radical cyclization process. Air is used as an efficient terminal oxidant in this transformation. The formation of 1,1-dibromoolefin derivatives was also realized at higher temperature under neat conditions.
已开发出催化量的叔丁基过氧化氢（TBHP，15摩尔%）促进的活性烯烃的三溴甲基化反应。该方法提供了一种无金属的需氧方法，通过一个拟议的串联自由基环化过程，由易得的N-芳基丙烯酰胺与CBr反应构建三溴甲基化的2-氧代吲哚。在该转化过程中，空气被用作一种有效的终端氧化剂。在纯反应条件下，较高温度下也实现了1,1-二溴烯烃衍生物的形成。
