Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
Biomedical Research Institute, Chonnam National University Hospital, Gwangju, Korea.
J Korean Med Sci. 2017 Oct;32(10):1708-1712. doi: 10.3346/jkms.2017.32.10.1708.
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA® XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
虽然细胞疗法已应用于心梗修复，但通过冠状动脉内输注的疗效有限。因此，我们使用左心室（LV）映射系统（NOGA® XP）建立了心肌内递送技术，该技术使用了 18 头猪。将脂肪组织来源的间充质干细胞（ATSCs）心肌内递送到猪梗死心脏后，LV 射血分数（EF）增加，LV 室腔大小减小。我们首次在韩国通过 LV 映射系统证明了心肌内注射 ATSC 的治疗效果。该技术的应用可能会加速其在不久的将来在临床应用中的转化。
