Área de Genética, Facultad de Ciencias, Instituto de Hortofruticultura Subtropical y Mediterranea 'La Mayora', Universidad de Málaga-Consejo Superior de Investigaciones Cientificas (IHSM-UMA-CSIC), Málaga, Spain.
Curr Issues Mol Biol. 2018;25:199-222. doi: 10.21775/cimb.025.199. Epub 2017 Sep 6.
Plant pathogenic bacteria are responsible for the loss of hundreds of millions of dollars each year, impacting a wide range of economically relevant agricultural crops. The plant immune system detects conserved bacterial molecules and deploys an arsenal of effective defense measures at different levels; however, during compatible interactions, some pathogenic bacteria suppress and manipulate the host immunity and colonize and infect the plant host. Different bacteria employ similar strategies to circumvent plant innate immunity, while other tactics are specific to certain bacterial species. Recent studies have highlighted the secondary messenger c-di-GMP as a key molecule in the transmission of environmental cues in an intracellular regulatory network that controls virulence traits in many plant pathogenic bacteria. In this review, we focus on the recent knowledge of the molecular basis of c-di-GMP signaling mechanisms that promote or prevent the evasion of bacterial phytopathogens from the plant immune system. This review will highlight the considerable diversity of mechanisms evolved in plant-associated bacteria to elude plant immunity.
植物病原细菌每年造成数十亿美元的损失，影响范围广泛的经济相关农业作物。植物免疫系统检测到保守的细菌分子，并在不同层面部署了一系列有效的防御措施；然而，在相容的相互作用中，一些病原细菌抑制和操纵宿主免疫，并定植和感染植物宿主。不同的细菌采用类似的策略来规避植物先天免疫，而其他策略则是特定于某些细菌物种的。最近的研究强调了 c-di-GMP 作为细胞内调控网络中环境信号传递的关键分子，该网络控制着许多植物病原细菌的毒力特征。在这篇综述中，我们专注于 c-di-GMP 信号机制的分子基础的最新知识，这些机制促进或阻止了细菌植物病原体逃避植物免疫系统。这篇综述将突出强调在与植物相关的细菌中进化出的逃避植物免疫的机制的巨大多样性。
