Cancer Center, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , China.
Department of Anesthesiology, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , China.
J Med Chem. 2018 Apr 12;61(7):2611-2635. doi: 10.1021/acs.jmedchem.6b01153. Epub 2017 Sep 20.
Carbon monoxide (CO) is attracting increasing attention because of its role as a gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing molecules (CORMs) are spatially and temporally controlled CO releasers that exhibit superior and more effective pharmaceutical traits than gaseous CO because of their chemistry and structure. Experimental and preclinical research in animal models has shown the therapeutic potential of inhaled CO and CORMs, and the biological effects of CO and CORMs have also been observed in preclinical trials via the genetic modulation of heme oxygenase-1 (HO-1). In this review, we describe the pharmaceutical use of CO and CORMs, methods of detecting CO release, and developments in CORM design and synthesis. Many valuable clinical CORMs formulated using macromolecules and nanomaterials are also described.
一氧化碳（CO）作为一种具有细胞保护和体内平衡特性的气体递质，引起了越来越多的关注。一氧化碳释放分子（CORMs）是空间和时间上受控的 CO 释放剂，由于其化学和结构，它们比气态 CO 具有更好、更有效的药物特性。动物模型的实验和临床前研究表明，吸入 CO 和 CORMs 具有治疗潜力，通过血红素加氧酶-1（HO-1）的遗传调控，也观察到 CO 和 CORMs 的生物学效应。在这篇综述中，我们描述了 CO 和 CORMs 的药物用途、CO 释放的检测方法以及 CORM 设计和合成的发展。还描述了许多使用大分子和纳米材料制成的有价值的临床用 CORMs。
