邻苯二甲酸二（2-乙基己基）酯（DEHP）暴露后γ-谷氨酰转肽酶（GGT）的研究。
Studies on gamma-glutamyl transpeptidase (GGT) after di(2-ethylhexyl) phthalate (DEHP) exposure.
作者信息
Parmar D, Srivastava S P, Seth P K
出版信息
J Appl Toxicol. 1987 Aug;7(4):249-51. doi: 10.1002/jat.2550070405.
Administration of Di(2-ethylhexyl)phthalate (DEHP) at doses of 250, 500, 1000 and 2000 mg/kg to adult rats was found to significantly increase the activity of gamma-glutamyl transpeptidase (GGT) in liver and serum in a dose-dependent manner. The data indicate that DEHP can be hepatotoxic since an increase in serum GGT levels are indicative of hepatobiliary dysfunction and liver malignancy. An assay of GGT in serum of the individuals exposed to DEHP could be helpful in early detection of liver disorders due to this widely used plasticizer.
给成年大鼠分别以250、500、1000和2000毫克/千克的剂量施用邻苯二甲酸二（2-乙基己基）酯（DEHP），结果发现肝脏和血清中的γ-谷氨酰转肽酶（GGT）活性显著增加，且呈剂量依赖性。数据表明，DEHP可能具有肝毒性，因为血清GGT水平升高表明存在肝胆功能障碍和肝脏恶性肿瘤。对接触DEHP的个体进行血清GGT检测，可能有助于早期发现由于这种广泛使用的增塑剂导致的肝脏疾病。
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