Okpataku Christopher Izehinosen, Tawani David
Department of Psychiatry, College of Health Sciences, Bingham University, Jos, Nigeria.
Department of Psychiatry, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Trends Psychiatry Psychother. 2017 Jul-Sep;39(3):165-172. doi: 10.1590/2237-6089-2016-0088. Epub 2017 Aug 31.
There is an unpredictable pattern in the prescription of antipsychotics and other psychotropic medications for the treatment of schizophrenia, particularly in resource-limited settings in developing countries.
To determine the psychotropic prescriptions given to patients with schizophrenia in an outpatient clinic of a tertiary hospital and to describe the choices and trends of these prescriptions.
This was a cross-sectional descriptive study of prescriptions for adults with schizophrenia. After clinical consultation, patients' case notes were randomly selected over a period of 2 years. Using a structured form, data were extracted from the case notes including biodemographic data, psychotropic medications prescribed and changes made to these prescriptions. Data were analyzed by means of descriptive statistics.
A total of 103 patients were selected, with a mean age of 35.96±9.78 years; 48.5% were males and 51.5% were females; 33% were unemployed and 38% had been hospitalized in the past. There were 231 initial prescriptions and 228 current prescriptions, with about 2.2 prescriptions per patient. Haloperidol (mean dose 14.77±6.28mg and 11.44±5.55mg for initial and current) and other old-generation antipsychotics were the most commonly prescribed for new cases (98%). Mean duration of psychotropic use was 7.78±5.6 years. All the patients were prescribed trihexyphenidyl, and 56.3% of the patients had their medications changed as a result of side effects.
There was a very high preference for the use of first-generation antipsychotics for all treatment settings (in- and outpatients), a pattern that is likely to persist.
在精神分裂症治疗中，抗精神病药物及其他精神药物的处方存在不可预测的模式，尤其是在发展中国家资源有限的环境中。
确定一家三级医院门诊为精神分裂症患者开具的精神药物处方，并描述这些处方的选择和趋势。
这是一项针对成年精神分裂症患者处方的横断面描述性研究。经过临床会诊后，在两年时间内随机抽取患者的病例记录。使用结构化表格从病例记录中提取数据，包括生物人口统计学数据、开具的精神药物以及这些处方的变更情况。通过描述性统计方法对数据进行分析。
共选取了103名患者，平均年龄为35.96±9.78岁；男性占48.5%，女性占51.5%；33%为失业人员，38%曾住院治疗。有231份初始处方和228份当前处方，每位患者约有2.2份处方。氟哌啶醇（初始和当前的平均剂量分别为14.77±6.28毫克和11.44±5.55毫克）及其他第一代抗精神病药物是新病例中最常开具的药物（98%）。精神药物的平均使用时长为7.78±5.6年。所有患者都开具了苯海索，56.3%的患者因副作用而更换了药物。
在所有治疗环境（门诊和住院）中，第一代抗精神病药物的使用偏好都非常高，这种模式可能会持续存在。
