Cash R, Raisman R, Cervera P, Javoy-Agid F, Agid Y
J Recept Res. 1987;7(1-4):527-54. doi: 10.3109/10799898709055001.
A number of neurotransmitter receptor sites have been characterized biochemically in post-mortem human brain from normal subjects and in several neurological and psychiatric diseases. Such studies are valid, however, only when appropriate pre-mortem and post-mortem conditions are controlled. The effects of age, pre-mortem agonic conditions, drug therapy and post-mortem delay on the characteristics of five binding sites (alpha-1, alpha-2 and beta adrenergic receptors, 5HT-2 serotoninergic receptors, imipramine binding sites) were studied. Age related changes in receptor number were found. Pre-mortem anoxia and hypovolemia had no influence on receptor characteristics. The drugs administered before death, in particular neuroleptics, were found to affect binding to some receptors in post-mortem tissue. A post-mortem delay up to 24 hours after death had no effect on binding sites. Experimental strategies (single point values or saturation curves) were also compared.
在正常受试者以及多种神经和精神疾病患者的尸检人脑组织中，已经对许多神经递质受体位点进行了生化特性鉴定。然而，只有在适当控制生前和死后条件时，此类研究才有效。研究了年龄、生前濒死状态、药物治疗以及死后延迟对五个结合位点（α-1、α-2和β肾上腺素能受体、5-羟色胺能5HT-2受体、丙咪嗪结合位点）特性的影响。发现了受体数量与年龄相关的变化。生前缺氧和血容量不足对受体特性没有影响。发现死亡前使用的药物，尤其是抗精神病药物，会影响死后组织中某些受体的结合。死后长达24小时的延迟对结合位点没有影响。还比较了实验策略（单点值或饱和曲线）。
