花生四烯酸抑制培养的小脑颗粒细胞对谷氨酸和谷氨酰胺的摄取，但不抑制对γ-氨基丁酸的摄取。
Arachidonic acid inhibits uptake of glutamate and glutamine but not of GABA in cultured cerebellar granule cells.
作者信息
Yu A C, Chan P H, Fishman R A
出版信息
J Neurosci Res. 1987;17(4):424-7. doi: 10.1002/jnr.490170414.
The effects of arachidonic acid (20:4) on the uptake of glutamate were studied in primary cultures of cerebellar granule cells and were compared to cortical neurons and astrocytes. At a dose of 0.005 mM, the glutamate uptake was significantly inhibited in cerebellar granule cells. This inhibition was dose and time dependent. The uptake of glutamate was equally sensitive to 20:4 in primary cell cultures of cortical neurons, whereas the uptake in astrocytes was much less sensitive to 20:4. Glutamine uptake was inhibited by 20:4 in cultured cerebellar granule cells and cerebral cortical astrocytes but was not affected in cerebral cortical neurons. Furthermore, the uptake of gamma-aminobutyric acid was not affected by 20:4 in cerebellar granule cells.
研究了花生四烯酸（20:4）对小脑颗粒细胞原代培养物中谷氨酸摄取的影响，并与皮质神经元和星形胶质细胞进行了比较。在0.005 mM的剂量下，小脑颗粒细胞中的谷氨酸摄取受到显著抑制。这种抑制作用具有剂量和时间依赖性。在皮质神经元原代细胞培养物中，谷氨酸摄取对20:4同样敏感，而星形胶质细胞中的摄取对20:4的敏感性则低得多。在培养的小脑颗粒细胞和大脑皮质星形胶质细胞中，谷氨酰胺摄取受到20:4的抑制，但在大脑皮质神经元中不受影响。此外，小脑颗粒细胞中γ-氨基丁酸的摄取不受20:4的影响。
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