TRPM2: Shredding the mitochondrial network.
作者信息
Li Fangfang, Abuarab Nada, Sivaprasadarao Asipu
机构信息
a School of Biomedical Sciences , Faculty of Biological Sciences, University of Leeds , Leeds , UK.
b Multidisciplinary Cardiovascular Research Centre , University of Leeds , Leeds , UK.
出版信息
Channels (Austin). 2017 Nov 2;11(6):507-509. doi: 10.1080/19336950.2017.1376982. Epub 2017 Oct 5.
Abstract
摘要
相似文献
1
TRPM2: Shredding the mitochondrial network.瞬时受体电位阳离子通道蛋白2：破坏线粒体网络
Channels (Austin). 2017 Nov 2;11(6):507-509. doi: 10.1080/19336950.2017.1376982. Epub 2017 Oct 5.
2
TRPM2-mediated rise in mitochondrial Zn promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents.TRPM2 介导线粒体 Zn 内流促进棕榈酸诱导的线粒体分裂和啮齿动物胰岛β细胞死亡。
Cell Death Differ. 2017 Dec;24(12):1999-2012. doi: 10.1038/cdd.2017.118. Epub 2017 Jul 28.
3
Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis.淀粉样β蛋白通过激活Akt诱导动力相关蛋白1磷酸化，促进过度的线粒体分裂，导致神经元凋亡。
Biochim Biophys Acta. 2016 Nov;1863(11):2820-2834. doi: 10.1016/j.bbamcr.2016.09.003. Epub 2016 Sep 4.
4
High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn-mediated mitochondrial fission.高糖诱导的 ROS 激活 TRPM2 引发溶酶体膜通透性增加和 Zn 介导的线粒体分裂。
Sci Signal. 2017 Aug 1;10(490):eaal4161. doi: 10.1126/scisignal.aal4161.
5
Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death.分化诱导因子3通过活性氧依赖的动力相关蛋白1介导的线粒体分裂和非半胱天冬酶依赖性细胞死亡来介导其抗白血病作用。
Oncotarget. 2016 May 3;7(18):26120-36. doi: 10.18632/oncotarget.8319.
6
Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System.DRP1-ZIP1 相互作用调控线粒体质量监控系统。
Mol Cell. 2019 Jan 17;73(2):364-376.e8. doi: 10.1016/j.molcel.2018.11.009. Epub 2018 Dec 20.
7
Curcumin Attenuates Hypoxia-Induced Oxidative Neurotoxicity, Apoptosis, Calcium, and Zinc Ion Influxes in a Neuronal Cell Line: Involvement of TRPM2 Channel.姜黄素减轻神经元细胞系缺氧诱导的氧化神经毒性、细胞凋亡及钙、锌离子内流：TRPM2 通道的参与。
Neurotox Res. 2021 Jun;39(3):618-633. doi: 10.1007/s12640-020-00314-w. Epub 2020 Nov 19.
8
TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death.瞬时受体电位阳离子通道M2型（TRPM2）介导的细胞内锌离子释放引发胰腺β细胞死亡。
Biochem J. 2015 Mar 15;466(3):537-46. doi: 10.1042/BJ20140747.
9
Targeted apoptosis in ovarian cancer cells through mitochondrial dysfunction in response to Sambucus nigra agglutinin.黑接骨木凝集素通过线粒体功能障碍诱导卵巢癌细胞发生靶向凋亡。
Cell Death Dis. 2017 May 4;8(5):e2762. doi: 10.1038/cddis.2017.77.
10
Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats.卵巢切除术诱导的大鼠海马体和背根神经节中通过 TRPA1、TRPM2 和 TRPV1 的线粒体氧化应激、细胞凋亡和钙离子内流可被 17β-雌二醇、他莫昔芬和雷洛昔芬预防。
Mol Neurobiol. 2017 Dec;54(10):7620-7638. doi: 10.1007/s12035-016-0232-5. Epub 2016 Nov 10.
引用本文的文献
1
Microvascular Alterations in Alzheimer's Disease.阿尔茨海默病中的微血管改变
Front Cell Neurosci. 2021 Jan 18;14:618986. doi: 10.3389/fncel.2020.618986. eCollection 2020.
本文引用的文献
1
High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn-mediated mitochondrial fission.高糖诱导的 ROS 激活 TRPM2 引发溶酶体膜通透性增加和 Zn 介导的线粒体分裂。
Sci Signal. 2017 Aug 1;10(490):eaal4161. doi: 10.1126/scisignal.aal4161.
2
TRPM2-mediated rise in mitochondrial Zn promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents.TRPM2 介导线粒体 Zn 内流促进棕榈酸诱导的线粒体分裂和啮齿动物胰岛β细胞死亡。
Cell Death Differ. 2017 Dec;24(12):1999-2012. doi: 10.1038/cdd.2017.118. Epub 2017 Jul 28.
3
TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death.瞬时受体电位阳离子通道M2型（TRPM2）介导的细胞内锌离子释放引发胰腺β细胞死亡。
Biochem J. 2015 Mar 15;466(3):537-46. doi: 10.1042/BJ20140747.
4
Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin.钙调神经磷酸酶对振荡性Ca2+信号的钙调蛋白控制的空间解码。
Elife. 2014 Jul 23;3:e03765. doi: 10.7554/eLife.03765.
5
Mitochondrial form and function.线粒体的形态和功能。
Nature. 2014 Jan 16;505(7483):335-43. doi: 10.1038/nature12985.
6
Mitochondrial dynamics--mitochondrial fission and fusion in human diseases.线粒体动力学——人类疾病中的线粒体分裂与融合
N Engl J Med. 2013 Dec 5;369(23):2236-51. doi: 10.1056/NEJMra1215233.
7
TRPM2: a multifunctional ion channel for calcium signalling.瞬时受体电位阳离子通道 M2 亚型：钙信号的多功能离子通道。
J Physiol. 2011 Apr 1;589(Pt 7):1515-25. doi: 10.1113/jphysiol.2010.201855. Epub 2010 Dec 6.
8
Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.线粒体网络可保护β细胞免受营养物质诱导的凋亡。
Diabetes. 2009 Oct;58(10):2303-15. doi: 10.2337/db07-1781. Epub 2009 Jul 6.
Zotero 插件