Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
Department of Ultrasound, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
Med Sci Monit. 2017 Sep 6;23:4304-4311. doi: 10.12659/msm.904755.
BACKGROUND Epicardial adipose tissue (EAT) is recognized as a useful indicator for type 2 diabetes mellitus (T2DM) and obesity. However, studies on the association between vitamin D status and EAT thickness in type 2 diabetes (T2D) are limited. In this study, we aimed to evaluate the association of vitamin D (Calcifediol) status and EAT thickness (EATT) in Chinese non-obese patients with T2D. MATERIAL AND METHODS A cross-sectional study was performed among 167 non-obese T2D Chinese patients and 82 non-diabetic patients, who are age- and gender-matched during the winter months. EATT was evaluated by two-dimensional transthoracic echocardiography. Serum 25-hydroxyvitamin D [25(OH)D, Calcifediol] was examined in the diabetic patients and in the control group. RESULTS The concentration of 25(OH)D was 32.00 nmol/l (19.30-53.70 nmol/l) among diabetic patients. Most (93.4%) of the diabetic patients had hypovitaminosis D. We confirmed a clear negative association between 25(OH)D level and EATT in non-obese T2D patients (p=0.01). EATT was significantly correlated with 25(OH)D level (p=0.001) and HOMA-IR (p=0.001). Results of multivariate logistic regression analysis demonstrated increased EATT, which was remarkably associated with 25(OH)D levels (p=0.039), systolic blood pressure (SBP) (p=0.013), HOMA-IR (p=0.030), and waist circumference (p<0.001) in T2D patients after adjusting for the confounding factors. CONCLUSIONS Increased EATT was found in Chinese T2D patients with normal BMI. 25(OH)D and HOMA-IR were independently associated with increased EATT after adjusting for multiple confounders.
心外膜脂肪组织（EAT）被认为是 2 型糖尿病（T2DM）和肥胖的有用指标。然而，关于维生素 D 状态与 2 型糖尿病（T2D）患者 EAT 厚度之间的关系的研究有限。在这项研究中，我们旨在评估中国非肥胖 2 型糖尿病患者的维生素 D（Calcifediol）状态与 EAT 厚度（EATT）之间的关系。
在冬季进行了一项横断面研究，共纳入 167 名非肥胖 2 型糖尿病中国患者和 82 名非糖尿病患者，这些患者在年龄和性别上与糖尿病患者相匹配。通过二维经胸超声心动图评估 EATT。在糖尿病患者和对照组中检查血清 25-羟维生素 D [25（OH）D，Calcifediol]。
糖尿病患者的 25（OH）D 浓度为 32.00 nmol/L（19.30-53.70 nmol/L）。大多数（93.4%）糖尿病患者患有维生素 D 缺乏症。我们在非肥胖 2 型糖尿病患者中证实了 25（OH）D 水平与 EATT 之间存在明显的负相关（p=0.01）。EATT 与 25（OH）D 水平显著相关（p=0.001）和 HOMA-IR（p=0.001）。多元逻辑回归分析结果表明，EATT 增加与 25（OH）D 水平（p=0.039）、收缩压（SBP）（p=0.013）、HOMA-IR（p=0.030）和腰围（p<0.001）显著相关，这些因素在调整混杂因素后与 T2D 患者的 EATT 增加有关。
在中国 BMI 正常的 2 型糖尿病患者中发现 EATT 增加。在调整多个混杂因素后，25（OH）D 和 HOMA-IR 与 EATT 增加独立相关。
