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群居环境中个体大鼠笼内活动及体温的自动记录：啮齿动物“老大哥”项目

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project.

作者信息

Redfern William S, Tse Karen, Grant Claire, Keerie Amy, Simpson David J, Pedersen John C, Rimmer Victoria, Leslie Lauren, Klein Stephanie K, Karp Natasha A, Sillito Rowland, Chartsias Agis, Lukins Tim, Heward James, Vickers Catherine, Chapman Kathryn, Armstrong J Douglas

机构信息

Drug Safety and Metabolism, AstraZeneca R&D, Babraham Research Campus, Cambridge, United Kingdom.

Drug Safety and Metabolism, AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom.

出版信息

PLoS One. 2017 Sep 6;12(9):e0181068. doi: 10.1371/journal.pone.0181068. eCollection 2017.

DOI:10.1371/journal.pone.0181068
PMID:28877172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5587114/
Abstract

Measuring the activity and temperature of rats is commonly required in biomedical research. Conventional approaches necessitate single housing, which affects their behavior and wellbeing. We have used a subcutaneous radiofrequency identification (RFID) transponder to measure ambulatory activity and temperature of individual rats when group-housed in conventional, rack-mounted home cages. The transponder location and temperature is detected by a matrix of antennae in a baseplate under the cage. An infrared high-definition camera acquires side-view video of the cage and also enables automated detection of vertical activity. Validation studies showed that baseplate-derived ambulatory activity correlated well with manual tracking and with side-view whole-cage video pixel movement. This technology enables individual behavioral and temperature data to be acquired continuously from group-housed rats in their familiar, home cage environment. We demonstrate its ability to reliably detect naturally occurring behavioral effects, extending beyond the capabilities of routine observational tests and conventional monitoring equipment. It has numerous potential applications including safety pharmacology, toxicology, circadian biology, disease models and drug discovery.

摘要

在生物医学研究中，通常需要测量大鼠的活动和体温。传统方法需要单笼饲养，这会影响它们的行为和健康状况。我们使用了皮下射频识别（RFID）应答器，在传统的、安装在架子上的饲养笼中对群居的大鼠个体进行动态活动和体温测量。应答器的位置和温度由笼子下方底板中的天线矩阵检测。一台红外高清摄像机获取笼子的侧视图视频，还能实现垂直活动的自动检测。验证研究表明，底板测得的动态活动与人工追踪以及侧视图全笼视频像素移动具有良好的相关性。这项技术能够在群居大鼠熟悉的饲养笼环境中持续获取个体行为和温度数据。我们证明了它能够可靠地检测自然发生的行为效应，超越了常规观察测试和传统监测设备的能力。它有许多潜在应用，包括安全药理学、毒理学、昼夜节律生物学、疾病模型和药物发现。

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