Munshi M H, Sack D A, Haider K, Ahmed Z U, Rahaman M M, Morshed M G
Lancet. 1987 Aug 22;2(8556):419-21. doi: 10.1016/s0140-6736(87)90957-3.
In an epidemic of shigellosis in southern Bangladesh the causal organism, Shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. The genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. This epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigellae are seldom resistant, and because plasmids were previously thought not to mediate resistance to nalidixic acid.
在孟加拉国南部的一次志贺氏菌病流行中，致病病原体痢疾志贺氏菌1型对萘啶酸、复方新诺明（甲氧苄啶-磺胺甲恶唑）和氨苄青霉素耐药。编码对萘啶酸耐药的基因位于一个20兆道尔顿的接合性质粒上，而编码对复方新诺明或氨苄青霉素耐药的基因则不在该质粒上。这次流行尤为重要，因为痢疾杆菌很少对萘啶酸耐药，而且此前认为质粒不会介导对萘啶酸的耐药性。
