肌萎缩性侧索硬化症中的仪器定时起立行走测试。
An instrumented timed up and go in facioscapulohumeral muscular dystrophy.
机构信息
Landon Center on Aging, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1005 Kansas City, Kansas, 66160, USA.
Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
出版信息
Muscle Nerve. 2018 Mar;57(3):503-506. doi: 10.1002/mus.25955. Epub 2017 Oct 6.
INTRODUCTION
Instrumenting timed functional motor tasks may reveal a continuum of motor disability that predicts future motor dysfunction.
METHODS
We performed a prospective study of the instrumented timed up and go (iTUG) test in genetically confirmed facioscapulohumeral muscular dystrophy (FSHD) participants using a commercially available system of wireless motion sensors. Patients returned within 2 weeks to determine test-retest reliability. Gait parameters in FSHD participants were compared with a normative database, FSHD clinical severity score, manual muscle testing, and patient-reported functional disability.
RESULTS
Gait parameters in FSHD participants were significantly (P < 0.05) altered compared with normative values, and reliability was excellent (intraclass correlation coefficient 0.84-0.99). Stride velocity and trunk sagittal range of motion had moderate to strong correlations to other FSHD disease measures.
DISCUSSION
The iTUG was reliable, abnormal in FSHD, and could distinguish between participants with differing disease severities. Instrumenting timed functional tasks may prove to be useful in FSHD clinical trials. Muscle Nerve 57: 503-506, 2018.
简介
对定时功能性运动任务进行仪器测量可能会揭示出一种连续的运动障碍，从而预测未来的运动功能障碍。
方法
我们使用一种商用的无线运动传感器系统，对经基因证实的面肩肱型肌营养不良症（FSHD）患者进行了仪器化计时起立行走（iTUG）测试的前瞻性研究。患者在 2 周内返回以确定测试-重测的可靠性。将 FSHD 参与者的步态参数与正常数据库、FSHD 临床严重程度评分、手动肌肉测试和患者报告的功能障碍进行比较。
结果
与正常值相比，FSHD 参与者的步态参数显著改变（P < 0.05），且可靠性极佳（组内相关系数 0.84-0.99）。步速和躯干矢状面运动范围与其他 FSHD 疾病测量指标具有中度至高度相关性。
讨论
iTUG 可靠，在 FSHD 中异常，并且可以区分不同疾病严重程度的参与者。仪器化定时功能性任务可能在 FSHD 临床试验中证明是有用的。肌肉神经 57: 503-506, 2018.
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