中药复方“解毒化瘀”颗粒对大鼠的亚慢性毒性
Subchronic toxicity of herbal compound "Jiedu Huayu" granules in rats.
作者信息
Wang Minggang, Qiu Hua, Zhang Rongzhen, Long Fuli, Mao Dewen
机构信息
Department of Liver Disease, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi Province, 530023, China.
出版信息
BMC Complement Altern Med. 2017 Sep 6;17(1):450. doi: 10.1186/s12906-017-1960-4.
BACKGROUND
"Jiedu Huayu" (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is to evaluate the safety of JDHY granules.
METHODS
Subchronic toxicity was tested in male and female rats that were orally administered three different doses (80, 100, and 130 g/kg/d) of JDHY for 13 weeks. Clinical signs, bodyweight, food consumption, hematological and biochemical parameters, organ coefficients, and histological changes were observed during the study.
RESULTS
There were no significant changes in toxicity observed in either sex at any dose of JDHY granules treatment.
CONCLUSIONS
These results suggest that repeated oral administration of JDHY granules at dosage levels of ≤130 g/kg/d can be considered safe.
背景
“解毒化瘀”（JDHY）颗粒是多年来一直用于治疗严重肝损伤的传统中药复方制剂。本研究的目的是评估JDHY颗粒的安全性。
方法
对雄性和雌性大鼠进行亚慢性毒性试验，大鼠口服三种不同剂量（80、100和130克/千克/天）的JDHY，持续13周。在研究过程中观察临床症状、体重、食物摄入量、血液学和生化参数、器官系数以及组织学变化。
结果
在任何剂量的JDHY颗粒治疗下，两种性别均未观察到明显的毒性变化。
结论
这些结果表明，以≤130克/千克/天的剂量重复口服JDHY颗粒可被认为是安全的。
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