Li Yong-Jiang, Ou Jian-Jun, Li Ya-Min, Xiang Da-Xiong
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, China.
Front Psychiatry. 2017 Aug 23;8:155. doi: 10.3389/fpsyt.2017.00155. eCollection 2017.
Autism spectrum disorders (ASDs) are a class of severe and chronic conditions and core symptoms are deficits in social interaction, language communication impairments, and repetitive/stereotyped behavior. Given the limitations of available treatments and substantially increased prevalence of the disease, additional interventions are needed. Since the use of dietary supplements for ASD is of high prevalence, up-to-date information about those supplements are required for both parents and clinicians. Relevant articles were identified through a systematic search of PubMed, EMBASE, Cochrane library, and PsychINFO databases (through May 2017). Current best evidences of 22 randomized controlled trials on 8 different dietary supplements for core symptoms of ASD were reviewed. For each supplement, this report focuses on the definition and potential therapeutic mechanisms, the latest advances, and discussion of study limitations and future directions. Most studies were small and short term, and there is little evidence to support effectiveness of dietary supplements for children with ASD.
自闭症谱系障碍（ASD）是一类严重的慢性疾病，其核心症状包括社交互动缺陷、语言交流障碍以及重复/刻板行为。鉴于现有治疗方法的局限性以及该疾病患病率的大幅上升，需要更多的干预措施。由于使用膳食补充剂治疗ASD的情况很普遍，家长和临床医生都需要有关这些补充剂的最新信息。通过系统检索PubMed、EMBASE、Cochrane图书馆和PsychINFO数据库（截至2017年5月）确定了相关文章。对关于8种不同膳食补充剂治疗ASD核心症状的22项随机对照试验的当前最佳证据进行了综述。对于每种补充剂，本报告重点关注其定义和潜在治疗机制、最新进展，以及对研究局限性和未来方向的讨论。大多数研究规模小且为期短，几乎没有证据支持膳食补充剂对ASD儿童有效的观点。
