阿尔茨海默病患者中微小RNA的表达及其与生物系统的相互作用。将微小RNA用作诊断和预后生物标志物。

miRNAs Expressions and Interaction with Biological Systems in Patients with Alzheimer`s Disease. Using miRNAs as a Diagnosis and Prognosis Biomarker.

作者信息

Negoita Silvius I, Sandesc Dorel, Rogobete Alexandru F, Dutu Madalina, Bedreag Ovidiu H, Papurica Marius, Ercisli Muhammed F, Popovici Sonia E, Dumache Raluca, Sandesc Mihai, Dinu Anca, Sas Adriana M, Serban Denis, Corneci Dan

出版信息

Clin Lab. 2017 Sep 1;63(9):1315-1321. doi: 10.7754/Clin.Lab.2017.170327.

DOI:10.7754/Clin.Lab.2017.170327

PMID:28879701

Abstract

BACKGROUND

A high percentage of patients develop Alzheimer`s disease (AD). The main signs are loss of memory and cognitive functions which have a significant impact on lifestyle. Numerous studies have been conducted to identify new biomarkers for early diagnosis of patients with AD. An ideal biomarker is represented by the expression of miRNAs. In this paper, we want to summarize expressions miRNAs in AD. We also want to present the pathophysiological and genetic interactions of miRNAs with protein systems in these patients.

METHODS

For the study, we examined available studies in scientific databases, such as PubMed and Scopus. The studies were searched using the keywords "miRNAs expression", "Alzheimer`s disease", "genetic polymorphisms", and "genetic biomarkers".

RESULTS

For the assessment and monitoring of patients with AD, the expression of miRNAs can be used successfully due to increased specificity and selectivity. Moreover, the expression of miRNAs can provide important answers regarding possible genetic interactions and genetic therapeutic regimens.

CONCLUSIONS

For the evaluation and non-invasive monitoring of patients with Alzheimer`s disease the expression of miRNAs can be successfully used.

摘要

背景

很大比例的患者会患上阿尔茨海默病（AD）。主要症状是记忆丧失和认知功能障碍，这对生活方式有重大影响。已经开展了大量研究以确定用于AD患者早期诊断的新生物标志物。理想的生物标志物以微小RNA（miRNA）的表达为代表。在本文中，我们想总结AD中miRNA的表达情况。我们还想阐述这些患者中miRNA与蛋白质系统的病理生理和遗传相互作用。