Chen Su-Yi-le, Su Guo-Zhu, Bai Rui-Feng, Yin Xu, Cao Yuan, Tu Peng-Fei, Chai Xing-Yun
Alashan League Mongolian Medicine Hospital, Alashan 750300, China.
Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029,China.
Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1246-1250. doi: 10.4268/cjcmm20160715.
One new iridoid, named alashanidoid A, and five known analogues, were isolated from the stem bark of Syringa pinnatifolia by various chromatographic methods. Their structures were determined on the basis of MS and NMR spectroscopic data analyses, and comparison with those in literature. Among them, compounds 3-5 were isolated from this genus for the first time, and 2 and 6 were isolated from the species for the first time.These isolates were tested for their in vitro anti-inflammatory activities against NO production in lipopolysaccharide(LPS)-induced RAW264.7 macrophages in mice and cytotoxicity of HepG2 cell line, however, no obvious activity was observed at the concentration of 40 μmol•L⁻¹.
通过各种色谱方法从紫丁香的茎皮中分离出一种新的环烯醚萜类化合物，命名为阿拉善环烯醚萜A，以及五种已知类似物。根据质谱和核磁共振光谱数据分析，并与文献中的数据进行比较，确定了它们的结构。其中，化合物3-5首次从该属中分离得到，化合物2和6首次从该物种中分离得到。对这些分离物进行了体外抗炎活性测试，检测其对小鼠脂多糖（LPS）诱导的RAW264.7巨噬细胞中一氧化氮产生的影响，以及对HepG2细胞系的细胞毒性，然而，在40μmol•L⁻¹的浓度下未观察到明显活性。
