Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, P. R. China.
Department of Pharmacy, Yanbian University Hospital, Yanji, P. R. China.
Nat Prod Res. 2020 Feb;34(4):518-524. doi: 10.1080/14786419.2018.1490903. Epub 2018 Nov 23.
A new secoiridoid, (1,5,8,9)-1-methyl-kingiside aglucone (), along with nine known compounds (-), were isolated from the ethanol extract of the stem bark of (Bl.) Hara. The structure of compound was elucidated using HR-ESI-MS, 1D and 2D NMR spectroscopy. Compounds - were evaluated for their inhibitory activity against NO, TNF-α and IL-6 production. Compounds , , and - significantly inhibited the levels of NO, TNF-α and IL-6 in LPS-induced RAW264.7 cells from concentrations of 3 to 30 μM.
从 (Bl.) Hara 的茎皮乙醇提取物中分离得到了一个新的环烯醚萜，（1,5,8,9）-1-甲基-金雀异苷配基（），以及九个已知化合物（-）。通过高分辨电喷雾质谱（HR-ESI-MS）、1D 和 2D NMR 光谱确定了化合物的结构。对化合物 - 进行了抑制 NO、TNF-α 和 IL-6 产生的活性评价。化合物 、 、 和 - 在浓度为 3 至 30 μM 时，显著抑制了 LPS 诱导的 RAW264.7 细胞中 NO、TNF-α 和 IL-6 的水平。
