Zhang Yu, Hu Wenteng, Wang Liwei, Han Biao, Lin Ruijiang, Wei Ning
Department of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
Biomark Med. 2017 Nov;11(11):967-977. doi: 10.2217/bmm-2017-0199. Epub 2017 Sep 7.
We investigated the role of GOLPH2 in non-small-cell lung cancer (NSCLC).
We analyzed the relationship between the expression of GOLPH2 and the clinical pathological characteristics of patients with NSCLC. The function of GOLPH2 in NSCLC cell lines was also explored through overexpression and knockdown studies.
The positive expression rate of GOLPH2 protein in NSCLC tissue was higher than that of normal lung tissue. We found that positive GOLPH2 expression was closely associated with unfavorable features of patients with NSCLC. The GOLPH2 expression was an independent predictor of the prognosis of patients with NSCLC. That GOLPH2 can promote the proliferation and invasion of NSCLC cells.
The GOLPH2 is a novel marker for NSCLC.
我们研究了高尔基体蛋白2（GOLPH2）在非小细胞肺癌（NSCLC）中的作用。
我们分析了GOLPH2表达与NSCLC患者临床病理特征之间的关系。还通过过表达和敲低研究探讨了GOLPH2在NSCLC细胞系中的功能。
NSCLC组织中GOLPH2蛋白的阳性表达率高于正常肺组织。我们发现GOLPH2阳性表达与NSCLC患者的不良特征密切相关。GOLPH2表达是NSCLC患者预后的独立预测因子。GOLPH2可促进NSCLC细胞的增殖和侵袭。
GOLPH2是NSCLC的一种新型标志物。
