Department of Geriatric Dentistry, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
J Clin Lab Anal. 2021 Nov;35(11):e24038. doi: 10.1002/jcla.24038. Epub 2021 Oct 7.
Laryngeal carcinoma (LC) is a common head and neck cancer, which is the result of mutational changes due to gene dysregulation and etiological factors such as tobacco and smoking. A large number of patients received a poor prognosis due to diagnosis at an advanced stage. This highlights the need for definitive, early, and efficient diagnoses. With rapid development of high-throughput sequencing, circular RNA (circRNA) has been reported to play a pivotal role in cancer. CircRNA functions as a microRNA (miRNA) sponge in the regulation of mRNA expression, forming circRNA-miRNA regulatory axis. In this review, we described the axis in LC. The result indicated that CDR1as, hsa_circ_0042823, hsa_circ_0023028, circPARD3, hsa_circ_103862, hsa_circ_0000218, circMYLK, circCORO1C, hsa_circ_100290, circ-CCND1, hsa_circ_0057481, circFLAN, and circRASSF2 expressed higher in LC, whereas, hsa_circ_0036722 and hsa_circ_0042666 expressed lower. The circRNAs regulated the target genes by sponging miRNAs and contributed to the pathogenesis of LC.
喉癌（LC）是一种常见的头颈部癌症，是由于基因失调和病因因素（如烟草和吸烟）导致突变变化的结果。由于晚期诊断，大量患者预后不良。这突出表明需要明确、早期和有效的诊断。随着高通量测序的快速发展，环状 RNA（circRNA）已被报道在癌症中发挥关键作用。circRNA 作为 microRNA（miRNA）在 mRNA 表达调控中的海绵，形成 circRNA-miRNA 调控轴。在这篇综述中，我们描述了 LC 中的该轴。结果表明，CDR1as、hsa_circ_0042823、hsa_circ_0023028、circPARD3、hsa_circ_103862、hsa_circ_0000218、circMYLK、circCORO1C、hsa_circ_100290、circ-CCND1、hsa_circ_0057481、circFLAN 和 circRASSF2 在 LC 中表达较高，而 hsa_circ_0036722 和 hsa_circ_0042666 表达较低。circRNAs 通过海绵 miRNA 调节靶基因，促进 LC 的发病机制。
