Zheng Peihe, Chen Yinbin, Fu Yangyang, Wang Hecheng, Wang Jia, Zheng Siwen, Xiao Shengyuan, Wang Yingping
1 Institute of Special Animal and Plant Sciences , Chinese Academy of Agricultural Sciences, Changchun, China .
2 School of Life Science, Beijing Institute of Technology , Beijing, China .
J Med Food. 2017 Nov;20(11):1127-1132. doi: 10.1089/jmf.2017.3922. Epub 2017 Sep 7.
After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used as added functional ingredients to try to improve the quality and price of functional foods. However, the interaction between different types of ginsenosides and nutrients needs further study. We investigated the effect of B-complex vitamins (which are essential nutrients) on the pharmacokinetics of the ginsenosides protopanaxatriol-type saponin Rg, protopanaxadiol-type saponin Rb, and oleanolic acid-type saponin Ro after oral administration. Ginsenosides Rg, Rb, and Ro, with or without B-complex vitamins, respectively, were administered orally to rats to evaluate their pharmacokinetics. The concentration of ginsenosides in plasma was determined by liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameters were fitted using WinNonlin v6.2. After oral coadministration with B-complex vitamins, the area under the concentration-time curve from zero to infinity (AUC) of ginsenoside Rg was reduced by 70%, that of ginsenoside Rb was reduced by 43%, and that of ginsenoside Ro was reduced by 34%. The AUC of ginsenosides Rg and Rb showed significant differences between different treatments, but the AUC of ginsenoside Ro did not. These results suggest significant ginsenoside-nutrient interactions between ginsenosides Rg, Rb, and B-complex vitamins.
人参种植后，人参的主要活性成分人参皂苷被食品工业批准使用，并开始用作添加性功能成分，试图提高功能性食品的质量和价格。然而，不同类型人参皂苷与营养素之间的相互作用需要进一步研究。我们研究了复合维生素B（必需营养素）对口服后原人参三醇型皂苷Rg、原人参二醇型皂苷Rb和齐墩果酸型皂苷Ro的药代动力学的影响。分别将含或不含复合维生素B的人参皂苷Rg、Rb和Ro口服给予大鼠以评估其药代动力学。通过液相色谱/串联质谱法测定血浆中人参皂苷的浓度。使用WinNonlin v6.2拟合药代动力学参数。与复合维生素B共同口服给药后，人参皂苷Rg从零至无穷大的浓度-时间曲线下面积（AUC）降低了70%，人参皂苷Rb降低了43%，人参皂苷Ro降低了34%。人参皂苷Rg和Rb的AUC在不同处理之间存在显著差异，但人参皂苷Ro的AUC没有。这些结果表明人参皂苷Rg、Rb与复合维生素B之间存在显著的人参皂苷-营养素相互作用。
