[人参皂苷Rg1在大鼠体内的药代动力学和生物利用度]

[Pharmacokinetics and bioavailability of ginsenoside Rg1 in rats].

作者信息

Tan Zhen-Yuan, Xiong Wang-Na, Huang Xing-Zhen, Liang Jian-Qin

机构信息

Guangxi Medical University, Nanning 530021, China.

Guangxi Health College, Nanning 530021, China.

出版信息

Zhong Yao Cai. 2013 Jul;36(7):1121-3.

PMID:24417150

Abstract

OBJECTIVE

To investigate the pharmacokinetics and bioavailability of ginsenoside Rg1 in rats.

METHODS

Ginsenoside Rg1 was oral administered or intravenous administered to each rat. The plasma concentration of ginsenoside Rg1 was estimated by RP-HPLC. 3P97 software was used to calculate pharmacokinetic parameters.

RESULTS

Main parameters of ginsenoside Rg1 after oral or intravenous administered were: AUC(0 --> t), 322.70 +/- 20.78, 99.76 +/- 8.91 microg x h/mL, CL 0.08 +/- 0.02, 3.01 +/- 0.69 L/(kg x h), V 0.23 +/- 0.01, 22.75 +/- 2.09 L/kg, t1/2alpha 0.48 +/- 0.18, 0.87 +/- 0.21 h, t1/2beta 19.57 +/- 2.81, 18.68 +/- 2.74 h, MRT6.91 +/- 0.99, 8.15 +/- 1.05 h(-1), respectively. The relative oral bioavailability of ginsenoside Rg1 was 2.5%.

CONCLUSION

The oral bioavailability of ginsenoside Rg1 is very low.

摘要

目的

研究人参皂苷Rg1在大鼠体内的药代动力学及生物利用度。

方法

对每只大鼠分别进行人参皂苷Rg1的口服给药或静脉给药。采用反相高效液相色谱法（RP-HPLC）测定人参皂苷Rg1的血浆浓度。使用3P97软件计算药代动力学参数。

结果

人参皂苷Rg1口服或静脉给药后的主要参数分别为：AUC(0→t)，322.70±20.78、99.76±8.91μg·h/mL；CL，0.08±0.02、3.01±0.69L/(kg·h)；V，0.23±0.01、22.75±2.09L/kg；t1/2α，0.48±0.18、0.87±0.21h；t1/2β，19.57±2.81、18.68±2.74h；MRT，6.91±0.99、8.15±1.05h⁻¹。人参皂苷Rg1的相对口服生物利用度为2.5%。