Bebak-Williams Julie, Bullock Graham L
a The Freshwater Institute , Post Office Box 1889 , Shepherdstown , West Virginia , 25443 , USA.
J Aquat Anim Health. 2002 Dec;14(4):294-297. doi: 10.1577/1548-8667(2002)014<0294:VAFIAC>2.0.CO;2.
Arctic char Salvelinus alpinus are susceptible to furunculosis, a serious bacterial disease that affects the productivity of salmonid farms around the world. The objective of this laboratory study was to evaluate the efficacy of a commercially available vaccine against furunculosis in two strains of Arctic char. Labrador and Nauyuk char were injected with Aqua Health Furogen 2 or 0.9% NaCl. At 87 and 108 d postvaccination, fish were challenged with Aeromonas salmonicida by immersion. In both challenges, the Aqua Health vaccine provided significant protection against furunculosis; percent cumulative mortality was significantly (P = 0.005) greater for the fish vaccinated with 0.9% NaCl than for those vaccinated with Furogen 2. Strain (P = 0.30), days since vaccination (P = 0.38), and the interaction between vaccine and strain (P = 0.40) were not significant. The point estimate for the preventive fraction (PF) was greater than 0.90 for the Labrador fish vaccinated with Furogen 2; for the Nauyuk fish, the PF was 0.89 and 0.38 at 87 and 108 d, respectively. Relative proportion survival values were also estimated and were usually similar to, but always lower than, the PF estimates.
北极红点鲑（Salvelinus alpinus）易患疖疮病，这是一种严重的细菌性疾病，影响着世界各地鲑鱼养殖场的生产力。本实验室研究的目的是评估一种市售疫苗对两种北极红点鲑菌株抗疖疮病的效果。给拉布拉多红点鲑和瑙约克红点鲑注射Aqua Health Furogen 2疫苗或0.9%的氯化钠溶液。在接种疫苗后87天和108天，通过浸泡法用杀鲑气单胞菌对鱼进行攻毒。在两次攻毒中，Aqua Health疫苗都提供了显著的抗疖疮病保护；接种0.9%氯化钠溶液的鱼的累积死亡率显著（P = 0.005）高于接种Furogen 2疫苗的鱼。菌株（P = 0.30）、接种疫苗后的天数（P = 0.38）以及疫苗与菌株之间的相互作用（P = 0.40）均不显著。接种Furogen 2疫苗的拉布拉多鱼的预防分数（PF）点估计值大于0.90；对于瑙约克鱼，在87天和108天时PF分别为0.89和0.38。还估计了相对比例存活值，其通常与PF估计值相似，但总是低于PF估计值。
