长链非编码 RNA DLX6-AS1 通过 miR-26a/PTEN 轴促进肾细胞癌进展。
Long noncoding RNA DLX6-AS1 promotes renal cell carcinoma progression via miR-26a/PTEN axis.
机构信息
a Department of Urology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
出版信息
Cell Cycle. 2017;16(22):2212-2219. doi: 10.1080/15384101.2017.1361072. Epub 2017 Sep 7.
Abstract
Recently, long non-coding RNAs (lncRNAs) have emerged as new gene regulators and prognostic markers in several types of cancer, including renal cell carcinoma (RCC). In this study, we identified an upregulated lncRNA, DLX6-AS1, in RCC tumor tissues compared with normal kidney tissues. Our data suggested that DLX6-AS1 promoted RCC cell growth and tumorigenesis via targeting miR-26a. In addition, we observed that PTEN overexpression restored the renal cancer cell growth and also rescued the RCC tumorigenesis. In summary, we conclude that DLX6-AS1 promotes renal cell carcinoma development via regulation of miR-26a/PTEN axis.
摘要
最近，长链非编码 RNA（lncRNA）在包括肾细胞癌（RCC）在内的多种类型的癌症中作为新的基因调节剂和预后标志物而出现。在这项研究中，我们发现 RCC 肿瘤组织中上调的 lncRNA，DLX6-AS1，与正常肾脏组织相比。我们的数据表明，DLX6-AS1 通过靶向 miR-26a 促进 RCC 细胞生长和肿瘤发生。此外，我们观察到过表达 PTEN 恢复了肾癌细胞的生长，并挽救了 RCC 的肿瘤发生。总之，我们得出结论，DLX6-AS1 通过调节 miR-26a/PTEN 轴促进肾癌细胞的发展。
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