长链非编码RNA HOTAIR通过直接结合肾细胞癌中的SAV1激活Hippo信号通路。
The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma.
作者信息
Hu Guanghui, Dong Binbin, Zhang Jingwei, Zhai Wei, Xie Tiancheng, Huang Bisheng, Huang Chi, Yao Xudong, Zheng Junhua, Che Jianping, Xu Yun-Fei
机构信息
Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Department of Urology, Yancheng Third People's Hospital, Yancheng, Jiangsu, China.
出版信息
Oncotarget. 2017 Apr 25;8(35):58654-58667. doi: 10.18632/oncotarget.17414. eCollection 2017 Aug 29.
The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surgery. HOTAIR promoted RCC cell proliferation and growth and . The expressions of HOTAIR and Salvador homolog 1 (SAV1) were inversely correlated in clinical RCC samples. HOTAIR downregulated SAV1 by directly binding to the SAV1 protein and enhanced histone H3K27 methylation. Loss of function of SAV1 activated the Hippo pathway. HOTAIR could be a potential therapeutic target in RCC.
长链非编码RNA HOTAIR促进多种肿瘤的发生和发展。在此，我们探讨了HOTAIR在肾细胞癌（RCC）肿瘤发生中的临床意义和作用。结果表明，HOTAIR表达增加预示着RCC术后预后不良。HOTAIR促进RCC细胞增殖和生长。在临床RCC样本中，HOTAIR与萨尔瓦多同源物1（SAV1）的表达呈负相关。HOTAIR通过直接结合SAV1蛋白下调SAV1，并增强组蛋白H3K27甲基化。SAV1功能丧失激活了Hippo通路。HOTAIR可能是RCC的一个潜在治疗靶点。
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