Dubois P M, Hemming F J
Reprod Nutr Dev (1980). 1987;27(2B):441-59.
The ontogenesis of the somatotropic function involving its regulatory hormones is considered from an anatomical and functional point of view. Embryogenesis of the hypothalamo-pituitary unit involving development of the hypothalamo-hypophyseal portal system is complete during early fetal life as shown in a certain number of mammalian species. The maturation of the neuroendocrine mechanisms controlling the secretion of fetal pituitary growth hormone is analyzed in the present paper. Corticosteroids may act directly on the differentiation of the somatotropic cells. During fetal life, the plasma level of GH is always higher than after birth. Despite large gaps in our knowledge, SRIF may play a prominent part in the regulation of the somatotropic function, sometimes mediating the effect of other factors, and GRF may also be active during late gestation. However, maturation is not complete until after birth especially that of somatomedins as well as the pulsatile release of GH.
从解剖学和功能学角度探讨了生长激素功能及其调节激素的个体发生。下丘脑 - 垂体单位的胚胎发生，包括下丘脑 - 垂体门脉系统的发育，在胎儿早期就已完成，这在一定数量的哺乳动物物种中得到了证实。本文分析了控制胎儿垂体生长激素分泌的神经内分泌机制的成熟过程。皮质类固醇可能直接作用于生长激素细胞的分化。在胎儿期，生长激素的血浆水平始终高于出生后。尽管我们的知识存在很大差距，但生长抑素可能在生长激素功能的调节中起重要作用，有时介导其他因素的作用，并且生长激素释放因子在妊娠后期也可能发挥作用。然而，直到出生后成熟才完成，尤其是生长调节素以及生长激素的脉冲式释放。
