Schwetz B A, Moorman M P
Teratog Carcinog Mutagen. 1987;7(3):211-23. doi: 10.1002/tcm.1770070304.
There is no general agreement at the present time regarding the role of maternal toxicity in the manifestation of teratogenic effects or developmental toxicity animal studies designed to identify the teratogenic potential of chemicals. A survey of 90 teratology studies published in the recent literature revealed wide differences in the amount and nature of maternal toxicity data collected in teratology studies. In addition, the use of the maternal toxicity data in the process of interpreting developmental toxicity varied widely between authors. In comparison with teratology studies, there is more uniformity in the collection of toxicity data in prechronic toxicity studies. The guidance provided by various government agencies on the parameters to be observed in prechronic toxicity studies is much more explicit than that provided regarding the collection of maternal toxicity data in teratology studies. Because of the likely importance of maternal toxicity in the conduct and interpretation of teratology studies, it is recommended that more maternal toxicity data be collected in teratology studies and the parameters be standardized between laboratories so that data are comparable. Guidelines should be established for the use of maternal toxicity data in the interpretation of the results of teratology studies.
目前，关于母体毒性在致畸作用表现或发育毒性方面的作用，在旨在确定化学物质致畸潜力的动物研究中尚无普遍共识。对近期文献中发表的90项致畸学研究进行的一项调查显示，致畸学研究中收集的母体毒性数据的数量和性质存在很大差异。此外，作者之间在解释发育毒性过程中对母体毒性数据的使用差异很大。与致畸学研究相比，慢性毒性前期研究中毒性数据的收集更为统一。各政府机构对慢性毒性前期研究中应观察的参数提供的指导比对致畸学研究中母体毒性数据收集提供的指导要明确得多。由于母体毒性在致畸学研究的进行和解释中可能具有重要意义，建议在致畸学研究中收集更多的母体毒性数据，并在各实验室之间对参数进行标准化，以便数据具有可比性。应制定关于在解释致畸学研究结果时使用母体毒性数据的指南。
