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成年急性T细胞白血病/淋巴瘤病情加重后出现的与全身性铁过载相关的焊工肺含铁血黄素沉着症。

Welder's pulmonary hemosiderosis associated with systemic iron overload following exacerbation of acute adult T-cell leukemia/lymphoma.

作者信息

Imoto Naoto, Shiraki Akira, Furukawa Katsuya, Tange Naoyuki, Murase Atsushi, Hayakawa Masaya, Iwata Yosuke, Kosugi Hiroshi

机构信息

Division of Hematology and Oncology, Ogaki Municipal Hospital.

Division of Respiratory Medicine, Ogaki Municipal Hospital.

出版信息

J Clin Exp Hematop. 2017 Oct 12;57(2):74-78. doi: 10.3960/jslrt.17024. Epub 2017 Sep 6.

Abstract

Herein, we describe a 61-year-old man diagnosed with pulmonary hemosiderosis following chemotherapy for acute adult T-cell leukemia/lymphoma (ATLL). Liver and heart biopsy confirmed hemosiderosis. ATLL progressed, and the patient died from multiorgan damage. Welder's lung may have been involved in hemosiderosis and systemic iron overload. Abnormal iron metabolism or immune reactions may have influenced the clinical course, but these were not validated. Detailed analyses of family medical and lifestyle histories, and genetic examination should be performed in cases of systemic iron overload.

摘要

在此,我们描述了一名61岁男性,他在接受急性成人T细胞白血病/淋巴瘤(ATLL)化疗后被诊断为肺含铁血黄素沉着症。肝脏和心脏活检证实有含铁血黄素沉着症。ATLL病情进展,患者死于多器官损害。焊工肺可能与含铁血黄素沉着症和全身铁过载有关。铁代谢异常或免疫反应可能影响了临床病程,但这些未得到证实。对于全身铁过载病例,应详细分析家族病史和生活方式史,并进行基因检测。

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本文引用的文献

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Iron and the liver.铁与肝脏
Liver Int. 2016 Jan;36 Suppl 1:116-23. doi: 10.1111/liv.13020.
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Use of magnetic resonance imaging to monitor iron overload.使用磁共振成像监测铁过载。
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Metal-induced diffuse lung disease.金属所致弥漫性肺疾病
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Systemic iron overload associated with Welder's siderosis.与焊工铁尘肺相关的全身性铁过载。
Am J Med Sci. 2009 Jan;337(1):57-9. doi: 10.1097/01.MAJ.0000308933.80112.49.
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Forging a field: the golden age of iron biology.开创一个领域:铁生物学的黄金时代。
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Body iron metabolism and pathophysiology of iron overload.机体铁代谢与铁过载的病理生理学
Int J Hematol. 2008 Jul;88(1):7-15. doi: 10.1007/s12185-008-0120-5. Epub 2008 Jul 2.

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