Imoto Naoto, Shiraki Akira, Furukawa Katsuya, Tange Naoyuki, Murase Atsushi, Hayakawa Masaya, Iwata Yosuke, Kosugi Hiroshi
Division of Hematology and Oncology, Ogaki Municipal Hospital.
Division of Respiratory Medicine, Ogaki Municipal Hospital.
J Clin Exp Hematop. 2017 Oct 12;57(2):74-78. doi: 10.3960/jslrt.17024. Epub 2017 Sep 6.
Herein, we describe a 61-year-old man diagnosed with pulmonary hemosiderosis following chemotherapy for acute adult T-cell leukemia/lymphoma (ATLL). Liver and heart biopsy confirmed hemosiderosis. ATLL progressed, and the patient died from multiorgan damage. Welder's lung may have been involved in hemosiderosis and systemic iron overload. Abnormal iron metabolism or immune reactions may have influenced the clinical course, but these were not validated. Detailed analyses of family medical and lifestyle histories, and genetic examination should be performed in cases of systemic iron overload.
在此,我们描述了一名61岁男性,他在接受急性成人T细胞白血病/淋巴瘤(ATLL)化疗后被诊断为肺含铁血黄素沉着症。肝脏和心脏活检证实有含铁血黄素沉着症。ATLL病情进展,患者死于多器官损害。焊工肺可能与含铁血黄素沉着症和全身铁过载有关。铁代谢异常或免疫反应可能影响了临床病程,但这些未得到证实。对于全身铁过载病例,应详细分析家族病史和生活方式史,并进行基因检测。