秘鲁4个城市中[具体内容缺失]鼻定植的患病率。
Prevalence of Nasal colonization with in 4 cities in Peru.
作者信息
Neyra Joan, Ellis Michael, Rocha Claudio, Silvera Juan, Apolaya Moisés, Bernal Maruja, Meza Rina, Canal Enrique, Meza Yocelinda, Blazes David
机构信息
Naval Medical Research Unit N° 6 Lima-Peru (NAMRU-6), 655 Manco Capac St., Miraflores, Lima Peru.
University of Toledo College of Medicine and Life Sciences, Toledo, USA.
出版信息
Trop Dis Travel Med Vaccines. 2016 Jul 22;2:12. doi: 10.1186/s40794-016-0025-x. eCollection 2016.
BACKGROUND
Antimicrobial resistance (AMR) is a growing public health threat around the world and is not well characterized in the developing setting. Specifically, there is a lack of information regarding nasal colonization with and methicillin-resistant (MRSA) in Latin America and Peru.
METHODS
This is the report of the baseline findings of a prospective cohort study followed up over 1 year at four geographically and ecologically distinct Peruvian Air Force bases in order to determine nasal colonization prevalence and risk factors. Additionally, all MRSA isolates underwent molecular analysis which included pulsed-field gel electrophoresis and determination of virulence and resistance genes.
RESULTS
We enrolled 756 military personnel. Anterior nares colonization with was detected in 73 of 756 participants (9.7 %) and MRSA was detected in 2 of 756 (0.3 %). Colonization rates differed significantly ( = 0.02) between geographic enrollment sites: Talara-4.3 %, Iquitos-9.1 %, Arequipa-14.0 % and Lima-11.3 %. Risk factors for S. aureus colonization included being male and a reported history of respiratory disease.
CONCLUSION
Overall, we found low prevalence of and MRSA nasal colonization in this Peruvian military population. These findings contribute to the overall epidemiological understanding of and MRSA in Latin America. The colonization rates which varied based on geographical location warrants further study.
背景
抗菌药物耐药性（AMR）是全球日益严重的公共卫生威胁，在发展中地区其特征尚不明确。具体而言，拉丁美洲和秘鲁缺乏关于鼻腔携带金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）的信息。
方法
这是一项前瞻性队列研究基线结果的报告，该研究在秘鲁四个地理和生态不同的空军基地进行了1年多的随访，以确定金黄色葡萄球菌鼻腔定植患病率和危险因素。此外，所有MRSA分离株均进行了分子分析，包括脉冲场凝胶电泳以及毒力和耐药基因的测定。
结果
我们纳入了756名军事人员。756名参与者中有73人（9.7%）检测到鼻腔前部金黄色葡萄球菌定植，756人中有2人（0.3%）检测到MRSA。不同地理招募地点的定植率差异显著（P = 0.02）：塔拉腊-4.3%，伊基托斯-9.1%，阿雷基帕-14.0%和利马-11.3%。金黄色葡萄球菌定植的危险因素包括男性和报告的呼吸系统疾病史。
结论
总体而言，我们发现该秘鲁军事人群中金黄色葡萄球菌和MRSA鼻腔定植的患病率较低。这些发现有助于对拉丁美洲金黄色葡萄球菌和MRSA的总体流行病学理解。基于地理位置而异的定植率值得进一步研究。
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