School of Pharmaceutical Sciences, Jiangnan University, Wuxi, 214122, People's Republic of China.
Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, Jiangnan University, Wuxi, 214122, People's Republic of China.
J Biomed Mater Res A. 2018 Jan;106(1):192-200. doi: 10.1002/jbm.a.36222. Epub 2017 Sep 28.
In this study, a series of poly(ethylene glycol)/collagen (PEG/Col) double network (DN) hydrogel is fabricated from PEG and Col. Results of the compressive strength test indicate that the strength and toughness of these DN hydrogels are significantly enhanced. The fracture strength of PEG/Col DN hydrogels increases by 9- to 12-fold compared with that of PEG single network (SN) hydrogel, and by 36- to 48-fold compared with that of Col SN hydrogel. Taking advantage of both PEG and Col building blocks, the PEG/Col DN hydrogels possess a strengthened skeleton. Moreover, the water-storage capability and favorable biocompatibility of Col are effectively maintained. Given that the DN hydrogels can provide the appropriate environment for the adhesion, growth, and proliferation of MC3T3-E1 cells, PEG/Col DN hydrogels have potential as a load-bearing tissue repair material. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 192-200, 2018.
在这项研究中，通过聚乙二醇（PEG）和胶原蛋白（Col）制备了一系列聚乙二醇/胶原蛋白（PEG/Col）双网络（DN）水凝胶。压缩强度测试的结果表明，这些 DN 水凝胶的强度和韧性得到了显著提高。与 PEG 单网络（SN）水凝胶相比，PEG/Col DN 水凝胶的断裂强度提高了 9 到 12 倍，与 Col SN 水凝胶相比提高了 36 到 48 倍。利用 PEG 和 Col 构建块，PEG/Col DN 水凝胶具有增强的骨架。此外，Col 的高吸水性和良好的生物相容性也得到了有效保留。鉴于 DN 水凝胶可为 MC3T3-E1 细胞的黏附、生长和增殖提供适宜的环境，PEG/Col DN 水凝胶有望成为一种承重组织修复材料。© 2017 年 Wiley 出版社。J 生物医学材料研究 A 部分：106A：192-200，2018 年。
