School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, Brazil.
Center for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ), Rio de Janeiro 21.941-902, Brazil.
Nutrients. 2017 Sep 8;9(9):989. doi: 10.3390/nu9090989.
The aim of this study was to compare the nutritional status of vitamin A per trimester of pregnancy, as well as to assess its influence on pre-pregnancy BMI, total gestational weight gain (TGWG) and presence of anemia in women who had previously undergone Roux-en-Y gastric bypass (RYGB). An analytical, longitudinal and retrospective study comprising 30 pregnant women who had previously undergone RYGB was undertaken. In all trimesters of pregnancy, the serum concentrations of retinol, β-carotene, stages of vitamin A deficiency (VAD), night blindness (NB), anemia and anthropometric variables were assessed. VAD in pregnancy affected 90% of women, 86.7% developed NB and 82.8% had mild VAD. TGWG above/below the recommended range was related to the low serum concentrations of β-carotene ( = 0.045) in the second trimester and women with TGWG above the recommended range showed 100% of inadequacy of this nutrient in the third trimester. Among the pregnant women with anemia, 90.9% had VAD and 86.4% had NB. This study highlights the importance of monitoring the nutritional status of vitamin A in prenatal care, due to its relationship with TGWG and the high percentage of VAD and NB found since the beginning of pregnancy. It also reaffirms the use of the cut-off <1.05 μmol/L for determining VAD.
本研究旨在比较妊娠各期维生素 A 的营养状况,并评估其对孕前 BMI、总孕期体重增加(TGWG)和贫血的影响。本研究为回顾性分析性研究,纳入了 30 名曾行 Roux-en-Y 胃旁路术(RYGB)的孕妇。在妊娠的所有阶段,均评估血清视黄醇、β-胡萝卜素、维生素 A 缺乏(VAD)分期、夜盲症(NB)、贫血和人体测量学变量。90%的孕妇妊娠时出现 VAD,86.7%发生 NB,82.8%有轻度 VAD。高于/低于推荐范围的 TGWG 与β-胡萝卜素血清浓度低有关(=0.045),在妊娠中期,高于推荐范围的 TGWG 孕妇在妊娠晚期 100%存在该营养素不足。贫血孕妇中,90.9%有 VAD,86.4%有 NB。本研究强调了在产前保健中监测维生素 A 营养状况的重要性,因为其与 TGWG 以及从妊娠早期就发现的高 VAD 和 NB 发生率有关。此外,该研究还证实了使用<1.05 μmol/L 作为 VAD 的截断值。